how does smoking cause LDL elevation????

Question

what is the mechanism through which smoking increases LDL in the circulation? could it poddibly involve a potential damage excerted upon LDL receptors? plz provide me with a satisfactory answer..... REEFERENCES PLAEASE!!!!!!!!!!!!

Answer 1

Smoking which causes HDL level to decrease causes LDL elevation indirectly.

As you know smoking decreases the HDL level. Looking back on what HDL does, it is said to protect the arteries from the atherosclerosis (caused by LDL) where HDL cholesterol extracts cholesterol particles from the artery walls and transports them to the liver to be disposed through the bile. It also interferes with the accumulation of cholesterol in the artery walls by the LDL cholesterol particles. That is the main reason there are treatments given to increase the HDL level.

It simply means that less HDL will result to less extraction of LDL from artery walls and less interference of LDL accumulation on the artery walls. LDL will go on its way thus elevating its level.

Potential damage to LDL receptors, of course very possible. Abnormally high LDL cholesterol levels in the blood would cause some "exhaustion" to the LDL receptors making it proned for damage.☺

Answer 2

Nicotinic acid, also called niacin or vitamin B3, is a potent lipid-lowering drug that works in the liver by affecting the production of blood fats. It's used to lower triglycerides and LDL cholesterol, and raise HDL ("good") cholesterol. Foods rich in niacin include: Meat and fish, Beans and lentils, Nuts, Fortified grains, whole-wheat bread, and fortified cereals, and Coffee

Answer 3

smoking doesn't elevate LDL.
smoking increases the amount of free oxygen radicals (ROS) in the bloodstream which in turn oxidise LDL- oxidised LDL is the type of LDL that links to scavenger receptors in monocytes (unlike HDL-sterified LDL), gets phagocyted and deposits (obviously inside the MPH) under the endothelium (and the subsequent process of inflammation, degradation into the necrotic atheromatous plaque).

ROS also cause endothelial disfunction (ROS are vasoconstrictors, and are lesive to the endothelium causing collagen exposure and upping coagulability).