Are there any known side-effects using glucosamine(1500mg/day) ???

Question

I have used it lately for my lower back issues on the premise that it may help
repair a herniated disk....

Answer 1

Clinical studies of glucosamine have consistently reported that glucosamine appears safe. Since glucosamine is usually derived from shellfish, those allergic to shellfish may wish to avoid it. However, since glucosamine is derived from the shells of these animals while the allergen is within the flesh of the animals, it is probably safe even for those with shellfish allergy (Gray et al. 1994). Alternative sources using fungal fermentation of corn are available. Another concern has been that the extra glucosamine could contribute to diabetes by interfering with the normal regulation of the hexosamine biosynthesis pathway (Buse, 2006), but several investigations have found no evidence that this occurs (Scroggie et al., 2003). The U.S. National Institutes of Health is currently conducting a study of supplemental glucosamine in obese patients, since this population may be particularly sensitive to any effects of glucosamine on insulin resistance. [4]. Finally, in the United States, glucosamine is sold as a dietary supplement, so safety and formulation is solely the responsibility of the manufacturer.

http://en.wikipedia.org/wiki/Glucosamine#Safety

Answer 2

2

Answer 3

People with diabetes should be a little cautious. Animal studies suggest a potential for raising blood sugar in some individuals. Otherwise, Glucosamine has an excellent safety record. A small number of users may experience mild GI upset, heartburn, nausea, diarrhea, and indigestion. This is usually solved by taking it with meals. Otherwise it is considered most effective when taken on an empty stomach.