explain????

Question

what are "naked" RNA strands or RNAi drugs
and stripped-down viruses

They are related to RNAi treatment

Answer 1

Just as it suggests.

Naked RNA is nothing but naked ribonucleic acid. RNA is a step in the genetic function of our bodies --- a messenger (mRNA) is transcribed off of our chromosomes, has some regions removed (exon splicing), and then is translated to a (generally) useful protein.

"Stripped down" virus is a very general term, and I assume it's referring to the same thing as naked RNA. Viruses are RNA or DNA inside protein coats, and when you strip them down, well, you get naked RNA or DNA!

RNAi stands for the principle of "RNA inhibition". In terms of science/research/medicine, we can artificially make RNA sequences that bind to and interfere with specific mRNA sequences. If we block up a specific mRNA sequence, you bet that its specific protein isn't going to be produced (as much, at least).

RNAi is a very new idea in medical treatment and could have uses in autoimmune diseases (such as multiple sclerosis and lupus). As an example, we could theoretically use certain RNAi sequences to block up mRNAs made by some immune cells, in order to decrease their activity. Each unique RNAi mRNA-blocker sequence, again in theory, should not interfere with other mRNA sequences. Therefore, the chances of side effects could be reduced.

Of course, there will still be side effects from decreasing the amount of said mRNA and its protein product.

However, as of now, RNAi is much more useful in research than it is in treatment. Look at the other side. If we "knock out" a useful mRNA sequence in a cell, what happens to that cell when it no longer has that protein to work with? (Actually, the process is formally called "knockdown", since RNAi cannot completely stop an mRNA from working.)