How much Latin should I be familiar with before I am able to read the Vulgate (what chapter in Wheelock's)?

Answer 1

I admit I haven't seen the Vulgate, but I would imagine you need all of Wheelock's and a lot of practice with literature. Wheelock's covers all of the grammar, but even if you know how the constructions work, it takes practice to handle them fluently. Good luck...that's something I hope to do one day myself as well.

Answer 2

Some, specially since it is not a late translation. Upper medieval Latin (Rome did not exist any more) is quite similar to the actual structure that Spanish has. But the Vulgate has a more classic Latin, that from the last days of Rome (IV to VI a.C.)