2006-11-09 11:47:19 · 6 answers · asked by anna l 1 in Health ➔ Diseases & Conditions ➔ Other - Diseases
Malignant hypothermia is caused by a mutation in the Ryanodine Receptor on the Sarcoplasmic Reticulum in muscle cells.
When certain general anaesthetics are administered (such and isoflurane and enflurane) they cause the mutant Ryanodine receptor to open. The RyR is a ligand gated calcium channel and the unnatural opening of it causes massive activation of the sarcomeres in the skeletal muscle. This leads to bodywide spasms and a huge increase in heat generated by the body (think: exercising makes you hot as well). This can be fatal as you are still under anaesthetic.
Another RyR-related disease is Myasthenia Gravis in which the RyR is poorly expressed at the genetic level due to an autoimmune reaction. It causes permanent lethargy.
2006-11-09 12:30:31 · answer #1 · answered by Anonymous · 2⤊ 0⤋
http://en.wikipedia.org/wiki/Malignant_hyperthermia
Malignant hyperthermia (MH or MHS for "malignant hyperthermia syndrome", or "malignant hyperpyrexia due to anesthesia") is a life-threatening condition resulting from a genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarizing neuromuscular blocking drugs that occurs during or after anaesthesia.
Edit: Hey, Wipipedia rocks! But you really should give the 10 pts to the person who has the PhD in Pharmacology. Interesting fact: In paramedic school, I was taught that Alaska Natives would tent to develop malignant hyperthermia as a result of administration of succylncholine.
2006-11-09 11:49:46 · answer #2 · answered by rita_alabama 6 · 0⤊ 0⤋
Please see the webpages for more details on Malignant hyperthermia and Heatstroke.
2006-11-09 21:39:21 · answer #3 · answered by gangadharan nair 7 · 0⤊ 0⤋
complete hell to experience and recover from for anyone who has.
2006-11-09 18:09:56 · answer #4 · answered by trust2400 3 · 0⤊ 0⤋
some thing very very cooll i bet
2006-11-09 12:13:13 · answer #5 · answered by rickalgo 1 · 0⤊ 0⤋
Oh my god. Rita_alab you're so clever!
2006-11-09 12:07:40 · answer #6 · answered by carnival queen 5 · 0⤊ 0⤋