how is Cimetidine prepared?

Answer 1

Cimetidine is prepared by reacting 4-methyl-5-[(2-aminoethyl) thiomethyl] imidazole, which is obtained by the reaction of 4-methyl-5-hydroxymethylimidazole on 2-aminoethanethiolsulfuric acid, with O-alkyl-S-alkyl-cyanothioimidocarbonate to give N-cyano-N'-[2-((4-methyl-5-imidazolyl) methylthio) ethyl]-O-alkylisourea, which is reacted with monomethylamine. According to the present process, cimetidine can be prepared in good yield and desired purity with very reduced amount of methyl mercaptan released from the reaction.♥
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If you mean administration preparation:
>> Check the 5 rights and the expiry dates.
>>For the tablet - check the required dose, and put it in a medicine cup and give p.o. to the patient,
>>For the liquid - shake it well and measure the correct volume and give p.o. to the patient.
>>For the parenteral route - check the dose, using the aseptic technique break the ampule and withdraw the required amount of solution to give then observe all the proper steps in giving intramuscular injections injections.
>>If to be given in continues intravenous infusions, your institution may had set its own standard with regards to its dilution. However, the simplest way you can do is to add the dosage per hour required in a volume of 60 ml so that it will be very easy to note that you will regulate the infusion into 1 ml per minute which would yield 60 micro drops/min or 15 drops per minute. The same thing if you are using intravenous infusion pumps or machines, add the dosage required for an hour in a 60 ml volume then your infusion setting will be 1 ml/minute.♥