2006-10-21 10:01:09 · 8 answers · asked by R M 1 in Science & Mathematics ➔ Medicine
Aspirin is a non-specific anti-inflammatory drug (NSAID). NSAIDs inhibit both cyclooxygenase-1 (COX-1) and COX-2 enzymes. Cyclooxygenase catalyses prostaglandin formation. Prostaglandins act (among other things) as messenger molecules in the inflammation process. The problem is that COX-1 is an important "house-keeping" enzyme, i.e. it plays a role in regulating many normal physiological processes. One of these is in the stomach lining, where prostaglandins prevent the stomach mucosa from being eroded by its own acid. Newer drugs, which inhibit only COX-2 bypass many of these problems... although there is some controversy as to how safe they are since ther may be some cardiovascular side-effects.
2006-10-21 22:16:38 · answer #1 · answered by Anonymous · 0⤊ 0⤋
Because Aspirin (being an anti-inflammatory drug) specifically inhibit the cycloxygenase enzyme that is needed for prostaglandin synthesis which promote inflammation. But prostaglandin is being produced constantly by your stomach so without it, some side effects are such as gastric bleeding which could probably cause nausea and vomiting
2006-10-22 01:46:18 · answer #2 · answered by costume_82 2 · 0⤊ 0⤋
It doesn't always, but it can because it is mildly irritating to the stomach. It can cause bleeding if the lining is irritated too much.
This is one of the reasons that for people taking aspirin as a daily precautionary drug, they recommend a low dose (81mg compared to the regular 325mg), and entericoated (EC) so that the aspirin is released in the intestinal tract rather than in the stomach so that irritation is less likely.
2006-10-21 18:29:00 · answer #3 · answered by Anonymous · 0⤊ 0⤋
Aspirin acts as a local irritant for the gastric mucous membrane, this is one of its major side effects, it gets entrapped in the cells of the gastric mucosa, called Ion trapping, as a result there is high intracellular concentration of aspirin or acetyl salicylic acid, causing ulceration and bleeding, in certain cases.
Hope that helped
2006-10-22 00:39:33 · answer #4 · answered by virgodoll 4 · 0⤊ 0⤋
It doesn't, usually. But, the chemical name for Aspirin is "acetylsalicylic acid", with acid being a mild irritant to the stomach at times. For those people who may be more prone to stomach upset, aspirin may trigger a stomach upset. For more info, see the below link.
2006-10-21 17:07:37 · answer #5 · answered by Jolly 7 · 0⤊ 0⤋
the acethylic acid from the aspirine has a lower pH so it make your stomach hurt
2006-10-21 19:57:10 · answer #6 · answered by a beautiful tragedy 2 · 0⤊ 0⤋
Paracetamol--It does not affect me but if so get Panadol.
2006-10-21 17:11:24 · answer #7 · answered by Boomer 2 · 0⤊ 0⤋
it makes your stomach bleed
2006-10-21 17:03:24 · answer #8 · answered by Buffy Summers 6 · 0⤊ 1⤋