The AIDS epidemic was discovered June 5, 1981, when the U.S. Centers for Disease Control and Prevention reported a cluster of Pneumocystis carinii pneumonia (now classified as Pneumocystis jiroveci pneumonia) in five homosexual men in Los Angeles. Originally dubbed GRID, or Gay-Related Immune Deficiency, health authorities soon realized that nearly half of the people identified with the syndrome were not homosexual men. In 1982, the CDC introduced the term AIDS to describe the newly recognized syndrome, though it was still casually referred to as GRID.
In 1983, scientists led by Luc Montagnier at the Pasteur Institute in France first discovered the virus that causes AIDS. They called it lymphadenopathy-associated virus (LAV). A year later a team led by Robert Gallo of the United States confirmed the discovery of the virus, but they renamed it human T lymphotropic virus type III (HTLV-III).[10] The dual discovery led to considerable scientific disagreement, and it was not until President Mitterrand of France and President Reagan of the USA met that the major issues were resolved. In 1986, both the French and the US names for the virus itself were dropped in favour of the new term, human immunodeficiency virus (HIV).
HIV was classified as a member of the genus lentivirus, part of the family of retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genome is converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integrase so that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latent and the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells.
Two species of HIV infect humans: HIV-1 and HIV-2. HIV-1 is thought to have originated in southern Cameroon after jumping from wild chimpanzees (Pan troglodytes troglodytes) to humans during the twentieth century.HIV-2 may have originated from the Sooty Mangabey (Cercocebus atys), an Old World monkey of Guinea-Bissau, Gabon, and Cameroon.HIV-1 is the most virulent. It is easily transmitted and is the cause of the majority of HIV infections globally. HIV-2 is less transmittable and is largely confined to West Africa. HIV-1 is the virus that was initially discovered and termed LAV.
Three of the earliest known instances of HIV-1 infection are as follows:
A plasma sample taken in 1959 from an adult male living in what is now the Democratic Republic of Congo.
HIV found in tissue samples from a 15 year old African-American teenager who died in St. Louis in 1969.
HIV found in tissue samples from a Norwegian sailor who died around 1976.
Although a variety of theories exist explaining the transfer of HIV to humans, no single hypothesis is widely accepted, and the topic remains controversial. Freelance journalist Tom Curtis discussed one controversial possibility for the origin of HIV/AIDS in a 1992 Rolling Stone magazine article. He put forward what is now known as the OPV AIDS hypothesis, which suggests that AIDS was inadvertently caused in the late 1950s in the Belgian Congo by Hilary Koprowski's research into a polio vaccine.Although subsequently retracted due to libel issues surrounding its claims, the Rolling Stone article motivated another freelance journalist, Edward Hooper, to probe more deeply into this subject. Hooper's research resulted in his publishing a 1999 book, The River, in which he alleged that an experimental oral polio vaccine prepared using chimpanzee kidney tissue was the route through which simian immunodeficiency virus (SIV) crossed into humans to become HIV, thus starting the human AIDS pandemic.
2006-10-20 03:49:26
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answer #1
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answered by Anonymous
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I'm not sure for certain. Ask Wikipedia, but I'll tell you this much. No one knows how AIDS first originated, because it's a virus that is passed on through direct body-fluid contact. It had to start somewhere, right? But where? Let me know if you find out anything.
2006-10-20 03:49:58
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answer #2
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answered by Link 4
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I don't know the facts, but I remember someone telling me that HIV/Aids was first discovered somewhere in Africa, and that supposedly those first infected had gotten the virus from monkeys?
It could be completely wrong though, maybe you could check an on line dictionary for facts?
2006-10-20 03:49:19
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answer #3
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answered by Anonymous
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in the late sixties a 16 year old teenager was taken to a san fransisco emergency room, it was found out later that he was a gay prostitute, he died in the hospital. they didnt know what he died from, they took tissue samples and froze them for later study, in the mid-eighties a sample of his tissue was tested for hiv-aids and was found to be positive. there is primate-i.v., human-i.v.,swine-i.v., feline-i.v., etc.
2006-10-20 03:56:53
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answer #4
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answered by hell oh 4
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The doctors who began doing tests on the homosexuals who were becoming ill right and left.
And don't believe the African monkey story, either.
2006-10-20 03:47:51
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answer #5
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answered by Anonymous
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