2006-10-19 00:21:03 · 2 answers · asked by Algebra 1 in Health ➔ Diseases & Conditions ➔ Other - Diseases
You can't beat the statistical odds.
1/4 chance of AA, 1/2 chance of AS, 1/4 chance of SS.
There is no way to select or diagnose an egg or sperm for the genotype. However, there is a way to increase the odds of having an AS or AA baby, without using donor sperm or eggs. But you have to be willing to put your ethics aside.
Here it is:
Using IVF, have several fertilised eggs implanted (2-3).
At about 8-12 weeks gestation, have chorionic villus sampling (CVS) and have this analysed for the genotype - this is a small part of the early placenta, and is the baby's tissue. It must be done using genetic sequencing, as ordinary testing for HbS will not be useful, because the haemoglobins are different at that age. You will then know which babies have AA, AS, or SS genotype. You can then have a selective termination based on these results, leaving only AS and AA babies. Clearly there is a possibility of having all of the babies as SS, although this would be very low, leading to possibly all the babies being terminated, or of having none of the babies as SS, in which case you would be having a very large family all at once.
I would not recommend this method, however, as there is a chance of causing a miscarriage collecting the CVS. Also the ethical considerations of terminating (ie killing) one or more babies while leaving the others is obviously hard to condone. But I know similar procedures to this have been done, for similar conditions.
Again, I only answer this because you asked.
Good health to you.
2006-10-19 01:40:37 · answer #1 · answered by Labsci 7 · 2⤊ 0⤋
As Genotype
2016-10-14 11:43:08 · answer #2 · answered by cardeiro 4 · 0⤊ 0⤋
This Site Might Help You.
RE:
what can a couple with AS genotype do to prevent them having an SS genotype baby.?
2015-08-19 04:33:42 · answer #3 · answered by Jenica 1 · 0⤊ 0⤋
nothing, as far as I know. I am assuming that both are AS. if so you have 25% chance of having SS baby. if one is AS and one SS the chance is 50%. if one is AS and one is normal there is no chance of having a baby with sickle cell disease, but 25% chance of having a baby with trait
2006-10-19 00:24:05 · answer #4 · answered by Anonymous · 0⤊ 0⤋