Drugs and transplant trials?

Question

How are people picked for drugs and transplant trials who already have a disease. i.e The transplant of a pigs pancreas into a diabetic. How did the diabetic know about the trial and why did they get picked?

I know about volunteering, but these things are different I'm sure.

Answer 1

Rules concerning this are very rigid, and then we are also governed by laws. First, we have feasibility studies to see whether the procedures or drugs warrant testing again the risks, then we use laboratory animals to solve the technical problems...nerves, veins, arteries, rejection, infection or simply failure in transplanted tissue. When the Chief of Surgery determines that the success rate is high enough, we begin to look for a group of patients....most are rejected as they are not strong enough to endure the procedure...in other words, we are stacking the deck so that we have a good chance to be successful but in honesty, we are attempting to cross a frontier that no one has before and while we want success, we also want to know that we are right in our premise. Finally, we select a patient and explain the risks of failure...and it must be knowing consent...that is the patient or his family must understand the risks and sign their permission...without that written permission, the hospital and doctors are liable for all legal actions....Drugs are easier but also tricky too. Medications are tested repeatedly on animals and finally we reach a testing point with a double blind study where neither the physician or the patient knows if they are being given a placebo or an actual drug...Nurses and technicians record all of the information during the test period. Of course such extensive testing is very expensive and it costs millions of dollars to put a new drug on the market. During the testing, every small detail is carefully analysed and put into computers. We then need to evaluate adverse reactions, side effects, incompatibility, safety levels....and barring unforeseen long term effects, we may have a new drug in our campaign again disease...Whether or not you become a participant in any experiment is voluntary, but some are paid....but each candidate is carefully selected and screened before any test begins.

Answer 2

I think it is done through your regular doctor. If you are a suitable candidate (right age etc) the doctor will refer you to the team of specialists who are doing the trials. They then will do a more detailsed assessment to see if you fit their very exacting criteria and if you do then things will start moving :)

Answer 3

I dont understand wat U want 2 kno if U kno abvt volunteering... No one can do a trial on a Patient/any Human without his/her will & Permission.. ie, volunteering...