Antidepressant effect of Diphenhydramine?

Question

Is it serotonergic? How much Diphenhydramine is equal to Fluoxetine 10mg? Which are the neurotransmitters affected? Does this drug help in withdrawal symptoms of SSRIs? Detailed information of Diphenhydramine related with Neuropsychiatry will be appreciated.
Please give me web addresses that give information related to this

Answer 1

In the 1960s it was found that diphenhydramine inhibits reuptake of the neurotransmitter serotonin. This discovery led to a search for viable antidepressants with similar structures and fewer side effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). A similar search had previously led to the synthesis of the first SSRI zimelidine from chlorpheniramine, also an antihistamine.

Answer 2

Diphenhydramine Antidepressant

Answer 3

Diphenhydramine does not have any anti-depressant effect. Every question you ask is off the wall. Who have you been talking to? They're ignorant!.

Diphenhydramine is an anti-histamine that blocks the release of histamine. Histamine is the chemical that is released when you come into contact with something you are allergic to. A side effect of diphenhydramine is that it tends to make you sleepy. That is why it is the active ingredient in all over the counter sleep aids.

I don't know who you are or why you are asking these questions, but you are badly misinformed.

Answer 4

I do not know where you can get the info unless you get it off of the net but Dipendyrdramine is actually call diphadryl. It helps to control your nerves much like a xanax or a valium. I have never ever seen it used for withdrawal symptoms. Oh yeah hats off to you smartassa that was a good one and I agree that the question was off the wall.

Answer 5

Diphenhydramine is an over-the-counter sleep aid that also has uses as an antihistamine, but I've never heard of it being touted as an antidepressant.

Answer 6

Fluoxetine dosing information

Usual Adult Dose for Bulimia:
Immediate-release oral formulations:Recommended dose: 60 mg orally once a dayComments:-Some patients may need to be started at a lower dose and titrated up over several days to the recommended dose-Daily doses greater than 60 mg have not been systematically studied for the treatment of BulimiaUse: Acute and maintenance treatment of binge-eating and vomiting behaviors in moderate to severe Bulimia Nervosa.
Usual Adult Dose for Depression:
Immediate-release oral formulations:Initial dose: 20 mg orally once a day, increased after several weeks if insufficient clinical improvement is observedMaintenance dose: 20 to 60 mg orally per dayMaximum dose: 80 mg orally per dayDelayed release oral capsules:Initial dose: 90 mg orally once a week, commenced 7 days after the last daily dose of immediate-release fluoxetine 20 mg formulations.Comments:-Doses above 20 mg per day may be given in divided doses, in the morning and at noon-The full effect may be delayed until after at least 4 weeks of treatment -If a satisfactory response with the once weekly oral fluoxetine is not maintained, a change back to daily fluoxetine dosing using the immediate-release oral formulations should be considered.-Acute episodes of Major Depressive Disorder require several months or longer of sustained pharmacologic therapy-Whether the dose needed to induce remission is the same as the dose needed to maintain and/or sustain euthymia is unknownUse: Acute and maintenance treatment of Major Depressive Disorder (MDD)
Usual Adult Dose for Obsessive Compulsive Disorder:
Immediate-release oral formulations:Initial dose: 20 mg orally once a day, increased after several weeks if insufficient clinical improvement is observed.Maintenance dose: 20 to 60 mg orally per dayMaximum dose: 80 mg orally per dayComments:-Doses above 20 mg per day may be given in divided doses, in the morning and at noon-The full effect may be delayed until after at least 5 weeks of treatmentUse: Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD)
Usual Adult Dose for Panic Disorder:
Immediate-release oral formulations:Initial dose: 10 mg orally once a day, increased after one week to 20 mg orally once a dayMaintenance dose: 20 to 60 mg orally per dayMaximum dose: 60 mg orally per dayComments:-Doses above 20 mg per day may be given in divided doses, in the morning and at noon-A dose increase may be considered after several weeks if no clinical improvement is observed.-Doses greater than 60 mg per day have not been systematically studied for the treatment of Panic DisorderUse: Acute treatment of Panic Disorder
Usual Adult Dose for Premenstrual Dysphoric Disorder:
Immediate-release oral formulations:Initial dose: Continuous regimen: 20 mg orally once a day on every day of the menstrual cycleCyclic regimen: 20 mg orally once a day starting 14 days prior to the anticipated start of menstruation through to the first full day of menses, and repeated with each new cycleMaintenance dose: 20 to 60 mg per day for either the continuous or intermittent regimensMaximum dose: 80 mg orally per dayDuration: The 20 mg daily dosage has been shown to be effective for up to 6 months of treatmentComments:-A daily dose of 60 mg has not been shown to be significantly more effective than 20 mg daily-Daily doses above 60 mg have not been systematically studied in patients with this condition
Usual Pediatric Dose for Depression:
Immediate-release oral formulations:8 to 18 years:Initial dose: 10 to 20 mg orally once a day; the 10 mg daily dose may be increased after one week to 20 mg orally once a dayLower weight children:Initial dose: 10 mg orally once a day, increased to 20 mg orally once a day after several weeks if insufficient clinical improvement is observedMaintenance dose: 10 to 20 mg orally once a dayComments:-The full effect may be delayed until after at least 4 weeks of treatment-The potential risks versus clinical need should be assessed prior to using this drug in children and adolescentsUse: Acute and maintenance treatment of Major Depressive Disorder (MDD)
Usual Pediatric Dose for Obsessive Compulsive Disorder:
7 to 18 years:Immediate-release oral formulations:Adolescents and higher weight children:Initial dose: 10 mg orally once a day, increased to 20 mg orally once a day after 2 weeksMaintenance dose: 20 to 60 mg orally per dayMaximum dose: 60 mg orally per dayLower weight children:Initial dose: 10 mg orally once a day, increased after several weeks if insufficient clinical improvement is observedMaintenance dose: 20 to 30 mg orally once a dayMaximum dose: 60 mg orally per dayComments:-Additional dose increases may be considered after several more weeks if clinical improvement is insufficient-Doses above 20 mg per day may be given in divided doses, in the morning and at noon-In lower weight children, there is minimal experience with doses greater than 20 mg per day, and none with doses greater than 60 mg per day-The full effect may be delayed until after at least 5 weeks of treatment-The potential risks versus clinical need should be assessed prior to using this drug in children and adolescentsUse: Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder


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