What type of Monoclonal Ab´s can be made? IgM, IgE, IgD, or only IgG?

Answer 1

That is a good question. I suggest you look at this link. It appears to be fairly helpful and may lead you to the answer. As MAbs are synthetic and essentially clones of the parent cells, MAbs of IgM, IgE, and even rat IgD are possible.

Answer 2

Maybe Genentech can answer most of ur questions....

Rituxan is the first of monoclonal antibodies to become commercially available for treatment of Lymphomas. This is a rather well tolerated drug that has shown reasonable efficacy against certain lymphomas. Rituxan is an antibody that selectively binds to CD-20 antigen on the surface of lymphoma cells. CD-20 is present in over 90% of low grade lymphomas. This drug also depletes normal CD-20 lymphocytes as well. Clinical trials with this drug have shown almost 50% response in patients who had have failed a prior chemotherapy and had progressive and refractory lymphoma. This drug is given intravenously, on a weekly basis for four weeks. The infusion should be slow and may be given in an out patient setting. Pre-medications with Tylenol and Benadryl should be used to prevent potential allergic reaction to this drug.