which pain killer is more powerfull &harmful among panadol and ibuprofen?

Question

what are the effects on body aft using pain killers?

Answer 1

panadol contains acemetaphine the ingredient in Tylenol, it is an excellent fever reducer and pain reliever. At high doses and taken with alcohol it can seriously damage your liver. Ibuprofen is a non-steroidal antiinflammatory and pain reducer, good for pain associated with sprains, arthritis any thing related to swelling. Its main draw is it is relatively gentle on ones stomach compared to anti-imflams such as indomethicin.

Answer 2

try co-codamol you can get it over the counter at the pharmacy, it contains a small amount of codeine and these are the strongest along with Solpadeine that you can get over the counter. if the pain doesn't get any better go to your doctor and ask for some co-drydamol or co-proximal. these should help. it's not good for your liver to be drinking and taking paracetamol, both are bad for the liver, and when you drink you can forget when you last took the paracetamol and could end up taking too many. though i do understand why you are doing it, nobody should suffer pain like this so i would go back to your doctor. hope you feel better soon. by the way paracetamol, sopladeine, co-codamol, co-proximal, and co-drydamol should only be taken 1g every 4 hours.

Answer 3

ibuprofen is it can eat away your stomach lining especially if you don't drink or eat with it. Panadol is paracetamol.

Answer 4

It is only a marginal and a relative difference. All pain killers adversely affect the functioning of kidneys.

Answer 5

don't know. I'd assume panadol because I've never heard of it.

Answer 6

all pain kill have side afect all of them harm you over time been there

Answer 7

I decide it would be best to read about both of them yourself.
I have found that information about drugs whether over the counter or precription, you need to read about it yourself.


Panadol Extra Strength Adult Pain Reliever, Caplets
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Package Details

Pain Reliever, Fever Reducer

* Easier to swallow coated caplets
* Contains: Acetaminophen ~ Pain Reliever, Fever Reducer
* 500 mg Caplets

Panadol is the official analgesic of the Olympic Team of Puerto Rico.

Questions? Toll Free 1-800-981-3511 weekdays.

Indications:

For the temporary relief of minor aches and pains associated with:

* headaches
* backache
* toothache
* menstrual cramps
* muscular aches
* minor arthritis pain
* common cold

For the reduction of fever.

Directions:

Do not take more than directed. (see overdose warning)

Adults and children 12 years of age and older take 2 caplets with water every 4-6 hours as needed. Do not take more than 8 caplets in 24 hours or as directed by a doctor.

Other information: Store at room temperature. Avoid excessive heat.

Ingredients:
Active Ingredients: (in each caplet): Acetaminophen 500mg (Pain reliever/fever reducer)

Inactive Ingredients: Hypromellose, Potassium Sorbate, Povidone, Pregelatinized Starch, Stearic Acid, Talc, Triacetin

Warnings:

Alcohol warning: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take acetaminophen or other pain relievers/fever reducers. Acetaminophen may cause liver damage.

Do not use:

* with any other product containing acetaminophen
* for more than 10 days for pain unless directed by a doctor
* for more than 3 days for fever unless directed by a doctor
* in children under 12 years of age

When using this product do not use more than directed. (see overdose warning)

Stop use and ask a doctor if:

* symptoms do not improve
* new symptoms occur
* pain or fever persists or gets worse
* redness or swelling is present

If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: Taking more than the recommended dose can cause serious health problems. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


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Ibuprofen
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Ibuprofen chemical structure
Ibuprofen
Systematic (IUPAC) name
2-[4-(2-methylpropyl)phenyl]propanoic acid
Identifiers
CAS number 15687-27-1
ATC code M01AE01
PubChem 3672
DrugBank APRD00372
Chemical data
Formula C13H18O2
Mol. weight 206.3 g/mol
Physical data
Melt. point 76°C (169°F)
Pharmacokinetic data
Bioavailability 49–73%
Protein binding 99%
Metabolism Hepatic
Half life 1.8–2 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) D(US)
Legal status

S2(AU) GSL(UK) OTC(US)
Routes Oral, rectal and topical

Ibuprofen (INN) (IPA: [ˈaɪbjuprofɛn]) is a non-steroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, fever, and as an analgesic, especially where there is an inflammatory component. Ibuprofen was developed by the research arm of Boots Group.
Contents
[hide]

* 1 Clinical use
o 1.1 Off-Label and investigational use
o 1.2 Ibuprofen lysine
* 2 Mechanism of action
* 3 Adverse effects
o 3.1 Reported adverse drug reactions
o 3.2 Photosensitivity
o 3.3 Cardiovascular risk
* 4 Stereochemistry
* 5 Human toxicology
* 6 Availability
* 7 Slang names
* 8 See also
* 9 References
* 10 External links

[edit]

Clinical use

Low doses of ibuprofen (200 mg., and sometimes 400 mg.) are available over the counter (OTC) in most countries. Ibuprofen has a dose-dependent duration of action of approximately 4–8 hours, which is longer than suggested by its short half-life. The recommended dose varies with body mass and indication. Generally, the oral dose is 200–400 mg (5–10 mg/kg in children) every 4–6 hours, up to a usual maximum daily dose of 800–1200 mg. Under medical direction, a maximum daily dose of 3200 mg may sometimes be used.
[edit]

Off-Label and investigational use

* As with other NSAIDs, ibuprofen may be useful in the treatment of severe orthostatic hypotension.[1]
* In some studies, ibuprofen showed superior results compared to placebo in the prophylaxis of Alzheimer's disease, when given in low doses over a long time.[2] Further studies are needed to confirm the results before ibuprofen can be recommended for this indication.
* Ibuprofen has been associated with a lower risk of Parkinson's disease, and may delay or prevent Parkinson's disease. Aspirin, other NSAIDs, and paracetamol had no effect on the risk for Parkinson's.[3] Further research is warranted before recommending ibuprofen for this use.

[edit]

Ibuprofen lysine

In Europe, Australia, and New Zealand ibuprofen lysine (ibuprofenlysinat, the lysine salt of ibuprofen) is licensed for treatment of the same conditions as ibuprofen. Ibuprofen lysine has been shown to have a more rapid onset of action compared to base ibuprofen.[4]
[edit]

Mechanism of action

Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2 ), ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa.

Main article: Non-steroidal anti-inflammatory drug
[edit]

Adverse effects

Ibuprofen appears to have the lowest incidence of gastrointestinal adverse drug reactions (ADRs) of all the non-selective NSAIDs. However, this only holds true at lower doses of ibuprofen, so over-the-counter preparations of ibuprofen are generally labelled to advise a maximum daily dose of 1,200 mg.

Main article: Non-steroidal anti-inflammatory drug
[edit]

Reported adverse drug reactions

In low single doses (200 to 400 mg) and daily doses of up to 1,200 mg the incidence of side effects is low. However, in patients treated on a long-term basis with more than 1,200 mg daily discontinuation rates are as high as 10 to 15%.

Common adverse effects include: nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhoea, headache, dizziness, salt and fluid retention, hypertension.[5]

Infrequent adverse effects include: oesophageal ulceration, heart failure, hyperkalaemia, renal impairment, confusion, bronchospasm, rash.[5]
[edit]

Photosensitivity

As with other NSAIDs, ibuprofen has been reported to be a photosensitising agent.[6][7] However, this only rarely occurs with ibuprofen and it is considered to be a very weak photosensitising agent when compared with other members of the 2-arylpropionic acids. This is because the ibuprofen molecule contains only a single phenyl moiety and no bond conjugation, resulting in a very weak chromophore system and a very weak absorption spectrum which does not reach into the solar spectrum.
[edit]

Cardiovascular risk

Along with several other NSAIDs, ibuprofen has been implicated in elevating the risk of myocardial infarction, particularly among those chronically using high doses.[8]
[edit]

Stereochemistry
3D model of (R)-ibuprofen
Enlarge
3D model of (R)-ibuprofen

Ibuprofen, like other 2-arylpropionate derivatives (including ketoprofen, flurbiprofen, naproxen, etc) contains a chiral carbon in the α-position of the propionate moiety. As such there are two possible enantiomers of ibuprofen with the potential for different biological effects and metabolism for each enantiomer.

Indeed it was found that (S)-(+)-ibuprofen (dexibuprofen) was the active form both in vitro and in vivo.

It was logical, then, that there was the potential for improving the selectivity and potency of ibuprofen formulations by marketing ibuprofen as a single-enantiomer product (as occurs with naproxen, another NSAID).

Further in vivo testing, however, revealed the existence of an isomerase which converted (R)-ibuprofen to the active (S)-enantiomer. Thus, due to the expense and futility that might be involved in marketing the single-enantiomer, most ibuprofen formulations currently marketed are racemic mixtures. A notable exception to this is Seractiv (Nordic Drugs).
[edit]

Human toxicology

Ibuprofen overdose has become common since it was licensed for over-the-counter use. There are many overdose experiences reported in the medical literature.[9] Human response in cases of overdose ranges from absence of symptoms to fatal outcome in spite of intensive care treatment. Most symptoms are an excess of the pharmacological action of ibuprofen and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, tinnitus, and nystagmus. Rarely more severe symptoms such as gastrointestinal bleeding, seizures, metabolic acidosis, hyperkalaemia, hypotension, bradycardia, tachycardia, atrial fibrillation, coma, hepatic dysfunction, acute renal failure, cyanosis, respiratory depression, and cardiac arrest have been reported.[10]. The severity of symptoms varies with the ingested dose and the time elapsed, however, individual sensitivity also plays an important role. Generally, the symptoms observed with an overdose of ibuprofen are similar to the symptoms caused by overdoses of other NSAIDs.

There is little correlation between severity of symptoms and measured ibuprofen plasma levels. Toxic effects are unlikely at doses below 100 mg/kg but can be severe above 400 mg/kg;[11] however, large doses do not indicate that the clinical course is likely to be lethal.[12] It is not possible to determine a precise lethal dose, as this may vary with age, weight, and concomitant diseases of the individual patient.

Therapy is largely symptomatic. In cases presenting early, gastric decontamination is recommended. This is achieved using activated charcoal; charcoal absorbs the drug before it can enter the systemic circulation. Gastric lavage is now rarely used, but can be considered if the amount ingested is potentially life threatening and it can be performed within 60 minutes of ingestion. Emesis is not recommended.[13] The majority of ibuprofen ingestions produce only mild effects and the management of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and renal function monitored.[11] Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, due to the fact ibuprofen is highly protein bound in the blood, there is minimal renal excretion of unchanged drug. Forced alkaline diuresis is therefore of limited benefit.[14] Symptomatic therapy for hypotension, GI bleeding, acidosis, and renal toxicity may be indicated. Occasionally, close monitoring in an intensive care unit for several days is necessary. If a patient survives the acute intoxication, he/she will usually experience no late sequelae.
[edit]

Availability

Ibuprofen was made available under prescription in the United Kingdom in 1969. In the years since, the good tolerability profile along with extensive experience in the community (otherwise known as Phase IV trials), has resulted in the rescheduling of small packs of ibuprofen to allow availability over-the-counter in pharmacies worldwide. Indeed there has been an increasing trend towards descheduling ibuprofen such that it is now available in supermarkets and other general retailers. The wider availability has meant that ibuprofen is now almost as commonly used as aspirin and paracetamol.
[edit]

Slang names
This section does not cite its references or sources.
You can help Wikipedia by introducing appropriate citations.

A standing joke about some athletes' regular use has produced "Vitamin I"[1] as a slang term for ibuprofen.

In the military, "Grunt Candy" is used as a slang name for ibuprofen, paracetamol, or naproxen.
[edit]

See also

* Paracetamol

[edit]

References

1. ^ Zawada E (1982). "Renal consequences of nonsteroidal antiinflammatory drugs.". Postgrad Med 71 (5): 223-30. PMID 7041104.
2. ^ Townsend K, Praticò D (2005). "Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.". FASEB J 19 (12): 1592-601. PMID 16195368.
3. ^ Chen H, Jacobs E, Schwarzschild M, McCullough M, Calle E, Thun M, Ascherio A (2005). "Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease.". Ann Neurol 58 (6): 963-7. PMID 16240369.
4. ^ Geisslinger G, Dietzel K, Bezler H, Nuernberg B, Brune K (1989). "Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid.". Int J Clin Pharmacol Ther Toxicol 27 (7): 324-8. PMID 2777420.
5. ^ a b (2004) Rossi S Australian Medicines Handbook, 2004, Australian Medicines Handbook. ISBN 0-9578521-4-2.
6. ^ Bergner T, Przybilla B. Photosensitization caused by ibuprofen. J Am Acad Dermatol 1992;26(1):114-6. PMID 1531054
7. ^ Thomson Healthcare. USP DI Advice for the Patient: Anti-inflammatory Drugs, Nonsteroidal (Systemic) [monograph on the internet]. Bethesda (MD): U.S. National Library of Medicine; c2006 [updated 2006 Jul 28; cited 2006 Aug 5]. Available from: http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202743.html
8. ^ Hippisley-Cox J, Coupland C (2005). "Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis.". BMJ 330 (7504): 1366. PMID 15947398.
9. ^ McElwee NE, Veltri JC, Bradford DC, Rollins DE. (1990). "A prospective, population-based study of acute ibuprofen overdose: complications are rare and routine serum levels not warranted.". Ann Emerg Med 19 (6): 657-62. PMID 2188537.
10. ^ Vale JA, Meredith TJ. (1986). "Acute poisoning due to non-steroidal anti-inflammatory drugs. Clinical features and management.". Med Toxicol 1 (1): 12-31. PMID 3537613.
11. ^ a b Volans G, Hartley V, McCrea S, Monaghan J. (2003). "Non-opioid analgesic poisoning". Clinical Medicine 3 (2): 119-23. PMID 12737366.
12. ^ Seifert SA, Bronstein AC, McGuire T. (2000). "Massive ibuprofen ingestion with survival.". J Toxicol Clin Toxicol 38 (1): 55-7. PMID 10696926.
13. ^ (2004). "Position paper: Ipecac syrup.". J Toxicol Clin Toxicol 42 (2): 133-43. PMID 15214617.
14. ^ Hall AH, Smolinske SC, Conrad FL, Wruk KM, Kulig KW, Dwelle TL, Rumack BH. (1986). "Ibuprofen overdose: 126 cases.". Ann Emerg Med 15 (11): 1308-13. PMID 3777588.

[edit]

External links

* U.S. National Library of Medicine: MedlinePlus Drug Information: Ibuprofen
* University of Bristol chemistry department page on Ibuprofen
* Ball and stick model
* Link page to external chemical sources.



NSAIDs (primarily M01A and M02A, also N02BA) edit

Salycilates: Aspirin (Acetylsalicylic Acid), Diflunisal, Ethenzamide -- Arylalkanoic acids: Diclofenac, Indometacin, Sulindac

2-Arylpropionic acids (profens): Carprofen, Flurbiprofen, Ibuprofen, Ketoprofen, Ketorolac, Loxoprofen, Naproxen, Tiaprofenic acid,

N-Arylanthranilic acids (fenamic acids): Mefenamic acid -- Pyrazolidine derivatives: Phenylbutazone

Oxicams: Meloxicam, Piroxicam -- Coxibs: Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib -- Sulphonanilides: Nimesulide

Topically used products: Diclofenac, Flurbiprofen, Ibuprofen, Indometacin, Ketoprofen, Naproxen, Piroxicam
Retrieved from "http://en.wikipedia.org/wiki/Ibuprofen"

Categories: Articles lacking sources | Non-steroidal anti-inflammatory drugs | Over-the-counter substances
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