Drug Information About Xanan and Zopiclone?

Question

Can anyone please tell me the fatal/lethal dose for Xanan and Zopiclone ? LD-50 would be okay. I need the information for writing my term paper in this sem.

Thank you very much.

Answer 1

Alprazolam is a short-acting drug in the benzodiazepine class used to treat anxiety disorders and as an adjunctive treatment for depression.

Alprazolam was invented by Pfizer and is marketed under the trade name Xanax. Its patent expired in September 1993
Alprazolam is a triazolobenzodiazepine, that is, a benzodiazepine with a triazolo-ring attached to its structure. Alprazolam binds to the GABAA subtype of the GABA receptor, increasing inhibitory effects of GABA within the central nervous system. The binding site for benzodiazepines is distinct from the binding site for barbiturates and GABA on the GABA receptor.

Unlike other benzodiazepines, alprazolam may also have some antidepressant activity, although clinical evidence of this is lacking.

The mechanism of action is not fully understood. Alprazolam is readily absorbed from the gastrointestinal tract. The peak plasma concentration is achieved in 1-2 hours. Most of the drug is bound to plasma protein, mainly albumin. Alprazolam is hydroxylated in the liver to α-hydroxyalprazolam, which is also pharmacologically active. This and other metabolites are later excreted in urine as glucuronides. Some of the drug is also excreted in unchanged form.

Dosage to a maximum of 3 mg daily, given in divided doses.
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Zopiclone (sold as Imovane®, Zimovane®) is a novel hypnotic agent used in the treatment of insomnia. It was first developed by Sepracor and introduced in 1988 by Rhône-Poulenc S.A., now part of Sanofi-Aventis. Zopiclone is a controlled substance in the United States, Canada and some European countries and may be illegal to possess without a prescription.

While it acts on the BZ1 receptor and is a short-acting hypnotic agent, it is not a benzodiazepine, but a cyclopyrrolone derivative, belonging to a novel chemical class which is structurally unrelated to existing hypnotics.

On April 4, 2005, the DEA listed zopiclone under Schedule IV, due to some evidence that the drug has addictive properties similar to benzodiazepines.

10 tablets may be fatal and this risk is greater if barbiturate use is combined with use of other downer drugs such as alcohol, heroin or tranquillisers.

Answer 2

just some info on the law the penalty for hacking into his phone is far worse than the penalty for sales or possesion of an illegal substance. If you want to do the right thing, report him, however if you are going to report him you should also report what you did. Otherwise you shouldn't even plan on going into a career with the police force.