relation of paget disease of bone and giant cell tumor .?

Question

G.C.T is a sometimes malignant tumor of bone I want to know that is there any relationship between this tumor and paget disease as the osteoclasts are involed and if there was there any research on the use of osteoclast inhibitors in treatment of these types of tumor or not

Answer 1

Can you please explain your question with a little more detail? Thank you.

Answer 2

I don't know haw specific of an answer you need, but I know that in general Giant Cell tumors are rare, except in people with Paget's disease. Both are conditions which allow the rapid growth of bone and both conditions are benign (non-cancerous.)

Answer 3

Benign huge cellular tumor: those tumors, which maximum ordinarily impact human beings of their 20s and 30s, happen contained in the epiphyses and would erode something of the bone and enlarge into the graceful tissues. huge cellular tumors are infamous for his or her tendency to recur. not often, a huge cellular tumor would metastasize, in spite of the indisputable fact that it remains histologically benign. Benign huge cellular tumors look lytic on x?ray. maximum benign huge cellular tumors are taken care of via curettage and packing with methyl methacrylate. If a tumor is amazingly great, finished excision may be needed. Malignant huge cellular tumor: Malignant huge cellular tumor, it extremely is uncommon, is generally located on the extreme end of a protracted bone. X?ray famous classic constructive factors of malignant destruction (predominantly lytic destruction, cortical destruction, tender-tissue extension, and pathologic fracture). A malignant huge cellular tumor that develops in a till now benign huge cellular tumor is often radioresistant. the comparable concepts of therapy notice as in osteosarcoma, however the treatment cost is low.