2006-09-12 14:07:35 · 4 answers · asked by Anonymous in Health ➔ General Health Care ➔ First Aid
Trimethoprim and sulfamethoxazole are two antibiotics that work together to create an optimal effect.
Trimethoprim’s method of action is to block the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is much stronger for the bacterial enzyme than the corresponding mammalian enzyme.
Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid. Thus the combination of trimethoprim and sulfamethoxazole inhibits two consecutive steps in the production of nucleic acids and proteins.
Trimethoprim and sulfamethoxazole is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
This drug is registered for use in humans, dogs, horses, cattle, and swine.
Human formulations: Bactrim® (Roche), Septra® (GlaxoWellcome), Cotrim Pediatric® (Lemmon), Sulfatrim® (URL and others), and generic preparations of Trimethoprim and Sulfamethoxazole.
Veterinary formulations: Tribrissen® and Tribrissen 400 Oral Paste (Schering-Plough), Di-Biotic® (Phoenix Pharmaceutical), Albon® (Pfizer Animal Health), Uniprim® Powder (Macleod), Tucoprim® Powder (Pharmacia & Upjohn), Borgal® (Hoechst), and generics
Trimethoprim and sulfamethoxazole should not be used in animals with known hypersensitivity or allergy to these or other sulfa drugs.
Trimethoprim and sulfamethoxazole should not be used in pregnant animals.
While generally safe and effective when prescribed by a veterinarian, trimethoprim and sulfamethoxazole can cause side effects in some animals. The following are known side effects organized by organ system:
Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.
Allergic Reactions: Epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported in humans.
Gastrointestinal: Hepatitis, including cholestatic jaundice and hepatic necrosis, elevation of serum transaminases and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Genitourinary: Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, and crystalluria.
Metabolic: Hyperkalemia, hyponatremia.
Neurologic: Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.
CNS: Depression, apathy, anxiety.
Endocrine: Cross-sensitivity may exist with diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. Diuresis and hypoglycemia have occurred in human patients receiving sulfonamides. Trimethoprim-sulfamethoxazole combination has been demonstrated to reduce thyroid hormone levels to below the normal reference range.
Musculoskeletal: Arthralgia and myalgia.
Respiratory System: Cough, dyspnea, and pulmonary infiltrates.
2006-09-12 14:10:40 · answer #1 · answered by kvsmiller 3 · 0⤊ 0⤋
yeah but dont medicate the cat on your own, consult the vet, the doses for humans way higher than for cats and your pills could be harmful
2006-09-12 14:18:05 · answer #2 · answered by Anonymous · 0⤊ 0⤋
heck i cant even pronaunce it
2006-09-12 14:09:21 · answer #3 · answered by ? 4 · 0⤊ 0⤋
I'm guessing......NO
2006-09-12 14:09:18 · answer #4 · answered by Diamond in the Rough 6 · 0⤊ 0⤋