Does Neurodex help emotional lability?

Answer 1

Labile affect or Pseudobulbar affect refers to the pathological expression of laughter, crying, or smiling. It is also known as '"Emotional Lability'", '"Pathological Laughter and Crying"', '"Emotional Incontinence'", or more recently Involuntary Emotional Expression Disorder (IEED)[1] . An individual may find themselves laughing uncontrollably at something that is only moderately funny, being unable to stop themselves for several minutes. Episodes may also be mood-incongruent; an individual might laugh uncontrollably when angry or frustrated, for example.

It is most commonly observed after brain injury or degeneration in the following conditions:

Amyotrophic lateral sclerosis (also known as motor neuron disease) - affects up to 50% of patients or up to 17,000 people, particularly those with pseudobulbar palsy[2];
Alzheimer's disease - affects up to 15% of patients (per Avanir Pharmaceuticals)
Multiple Sclerosis (MS) - affects up to 10% of patients (per Avanir Pharmaceuticals)
Stroke - affects up to 11% of patients (per Avanir Pharmaceuticals)
While not as profoundly disabling as the physical symptoms of these diseases, labile affect can have a significant impact on individuals' social functioning and their relationships with others. In a disease such as Motor Neuron Disease, the majority of patients are cognitively normal; however, the appearance of uncontrollable emotions is commonly associated with learning disabilities. This may lead to severe embarrassment and avoidance of social interactions for the patient, which in turn has an impact on their coping mechanisms and their careers.

Treatment is usually pharmacological, using anti-depressants such as fluoxetine, citalopram, or amitriptyline in low to moderate doses. A new potential treatment, called NEURPDEX, has completed trials in the United States[2]; A randomised double-blind placebo-controlled trial led by Professor Benjamin Brooks in MND found that emotionally labile episodes were reduced by about 50%, leading to an improvement in both quality of life and quality of relationships. One significant data point is that per Avanir Pharmaceuticals' public disclosures on this trial, 24% of the patients given Neurodex dropped out during the four week trial period due to adverse events. This was versus 6% to 8% for patients recieving something other than Neurodex. Adverse events reported for Neurodex included nausea, dizziness, somnolence, and diarrhea. All of these adverse events resolved when therapy was discontinued. Preliminary results suggest a similar profile of efficacy in multiple sclerosis

Answer 2

It has been reported recently (April and June 2006 the most recent occasions) that Neurodex does have some benefits in dealing with Involuntary Emotional Expression Disorder (Emotional Lability), and the company that produces it has applied to have it recognised as a treatment for the same.

See the link below for more information. (Sorry, it may appear technical to the lay person, but I think you'll get the gist of what it's saying.)

Answer 3

read this site.....http://www.thisisms.com/modules.php?name=News&file=article&sid=27