Purkinje cells are a class of GABAergic neuron located in the cerebellar cortex. They are named after their discoverer, Czech anatomist Jan Evangelista Purkyně. These cells are some of the largest neurons in the brain, with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines. Purkinje cells are found within the Purkinje layer in the cerebellum. Purkinje cells are aligned like dominos stacked one in front of the other. Their large dendritic arbors form nearly two dimensional layers through which parallel fibers from the deeper-layer granule cells pass. These parallel fibers make relatively weaker excitatory (glutamatergic) synapses to spines in the Purkinje cell dendrite, whereas climbing fibers originating from the inferior olivary nucleus in the medulla provide very powerful excitatory input to the proximal dendrites and cell soma. Parallel fibers pass orthogonally through the Purkinje neuron's dendritic arbor, with up to 200,000 parallel fibers forming a synapse with a single Purkinje cell. Alternatively, each Purkinje cell only receives a synapse from a single climbing fiber. Both basket and stellate cells (found in the cerebellar molecular layer) provide inhibitory (GABAergic) input to the Purkinje cell, with basket cells synapsing on the Purkinje cell body and stellate cells onto the dendrites. Purkinje cells send inhibitory projections to the deep cerebellar nuclei, and constitute the sole output of all motor coordination in the cerebellar cortex.
2006-09-02 16:26:19
·
answer #1
·
answered by Anonymous
·
0⤊
0⤋
http://en.wikipedia.org/wiki/Purkinje_fibers
http://en.wikipedia.org/wiki/Purkinje_cell
The purkinje fibers are in the heart. Purkinje cells forming the purkinje layer are in the cerebellum.
2006-09-01 17:37:01
·
answer #2
·
answered by finaldx 7
·
0⤊
0⤋
What Is Purkinje
2017-02-25 14:17:06
·
answer #3
·
answered by ? 4
·
0⤊
0⤋
It is a class of neuron in the cerebellum; the only neurons that convey signals away from the cerebellum.
found in the cerebellar molecular layer
2006-09-01 16:20:47
·
answer #4
·
answered by Anonymous
·
0⤊
0⤋
the purkinje fibres r located in the heart to help conduct the impulses from the atria to the ventricles...
2006-09-02 03:33:45
·
answer #5
·
answered by Amna Z 3
·
0⤊
1⤋
we have purkinje cells in cerebellum. and purkinje fibers in conducting system of our heart.
hope this helps
2006-09-02 02:41:15
·
answer #6
·
answered by Anonymous
·
1⤊
0⤋
there are purkinje cells in the cardiac muscles
2006-09-09 13:53:23
·
answer #7
·
answered by buji ph 1
·
0⤊
1⤋
In the cerebellum cortex where their axons synapse with output neurons that issue to the brainstem.
2006-09-06 07:39:07
·
answer #8
·
answered by tampagirl1015 2
·
0⤊
0⤋
its the 3rd layer in cerebellum
its also present in cerebrum 4th layer
2006-09-01 17:51:36
·
answer #9
·
answered by Gundruk 3
·
0⤊
0⤋
Read all about it at Wikipedia:
http://en.wikipedia.org/wiki/Purkinje_cell
2006-09-01 16:18:35
·
answer #10
·
answered by Richard B 7
·
0⤊
0⤋