Explain four steps involved in beta oxidation?

Question

Beta oxidation is also called fatty acid oxidation.You should atleast include enzymes that catalyze the individual reactions.Be simple and straightforward.

Answer 1

1) Release from adipose tissue:

Lipolysis of free fatty-acids occur and its products are released into the bloodstream. This leads to the synthesis of ketones, which leads to ketosis.

2) Transport into Mitochondria:

In order for this process to occur, fatty acids must be activiated by way of oxidation. This process occurs in two steps:

* Fatty Acid ------> Acyl Adenylate
* Acyl Adenylate --------> Acyl CoA

Once activated, Acyl CoA is transported into the Mitochondrial matrix.

3) Beta-Oxidation occurs in 4 Steps

* Oxidation by FAD
* Hydration
* Oxidation by NAD+
* Thiolysis

Answer 2

Beta Oxidation Steps

Answer 3

http://www.gwu.edu/~mpb/betaox.htm

Beta-Oxidation of Fatty Acids (even chain)

Palmitoyl-CoA (16:0)


trans-D2-Palmitenoyl-CoA (16:1tD2)


L-3-Hydoxypalmitoyl-CoA


3-Ketopalmitoyl-CoA


Myristoyl-CoA (14:0)


trans-D2-Myristenoyl-CoA (14:1tD2)


L-3-Hydoxymyristoyl-CoA


3-Ketomyristoyl-CoA


Lauroyl-CoA (12:0)


trans-D2-Laurenoyl-CoA (12:1tD2)


L-3-Hydoxylauroyl-CoA


3-Ketolauroyl-CoA


Caproyl-CoA (10:0)


trans-D2-Caprenoyl-CoA (10:1tD2)


L-3-Hydroxycaproyl-CoA


3-Ketocaproyl-CoA


Capryloyl-CoA (8:0)


trans-D2-Caprylenoyl-CoA (8:1tD2)


L-3-Hydroxycapryloyl-CoA


3-Ketocapryloyl-CoA


Hexanoyl-CoA (6:0)


trans-D2-Hexenoyl-CoA (6:1tD2)


L-3-Hydroxyhexanoyl-CoA


3-Ketohexanoyl-CoA


Butanoyl-CoA (4:0)


trans-D2-Butenoyl-CoA (4:1tD2)


3-Hydroxybutanoyl-CoA


3-Ketobutanoyl-CoA



Acetyl-CoA + Acetyl-CoA