what is enzym efflux?

Question

enzym efflux affecting on delay onset muscle soreness on exercise

Answer 1

DOMS (Delayed Onset Muscle Soreness) is thought to be caused from lactic acid buildup caused by enzyme efflux. Whether this can be reduced with Creatine supplimentation was discussed at length in a paper presented at the 22nd Annual National Strength & Conditioning Association Meeting in Kansas City, MO, on June 25,1999

The abstract is found here:
EFFECTS OF LONG-TERM CREATlNE SUPPLEMENTATION DURING TRAINING ON MARKERS OF CATABOLlSM AND ENZYME EFFLUX

J. Ransom, R. Kreider, C. Rasmussen, C. Melton, T. Stroud, E. Cantier, M. Greenwood & P. Milnor.
Exercise & Sport Nutrition Laboratory, Department of HMSE, University of Memphis, Memphis, TN 38152.

Some studies indicate that creatine supplementation during training may increase muscle and/or liver enzyme eff!ux. This study examined the effects of long-term creatine supplementation on markers of catabolism and muscle/liver enzyme eflux in athletes who suppiemented their diet with creatine for 18-wk during preseason and in-season college football training. 49 division IA football players participated in this long-term open label study to evaluate the medical safety of creatine supplementation. 33 subjects ingested supplements containing 15.75 g/d of creatine for 5-d, 5.25 g/d of creatine for 20-d, 8.3 g/d of creatine for 14-d, and 5.25 g/d of creatine for 87-d. 16 subjects served as controls and were provided a carbohydrate/protein supplement with no creatine. Supplements were administered following daily workouts. Training invotved 4-5 d/wk (70a7 min/d) of resistance-training and sprint/agilEty conditioning during pre-camp, training, practicing 2 to 3 times per day for 14-d during preseason football camp (207217 min/d, 6 dlwk), and practicing/playing (12718 minld, 6 dlwk) during in-season training. Prior to and following each phase of training, subjects donated fasting blood samples. Serum samples were analyzed for urea nitrogen (BUN), creatinine, uric acid, creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Data were analyzed by repeated measures ANOVA with LSD post-hoc analysis. Results revealed no significant differences (‘0.05) between creatine users and nonusers in serum BUN, creatinine, CK, LDH, AST, or ALT levels. However, the ratio of BUN/creatinine (which serves as a general marker of anabolic/catabolic status) was significantly higher in the non-creatine users group following phase I & II of training while being unchanged in the creatine group. Results indicated that creatine supplementation during pre-season and in-season college football training does not adversely affect serum muscle & liver enzyme efflux and may allow an athlete to experience less catabolism during intense periods of training.

Reference Ransom, J., R. Kreider, C. Rasmussen, C. Melton, T. Stroud, E, Cantler, ‘M. Greenwood & P. Milnor. Effects of long-term creatine supplementation during training on markers of catabolism and enzyme efflux. Journal of Strength and Conditioning Research. 13: 431, 4999.