What does clonal abnormality 46, xy, del (2) (p21p23) in 12/21 metaphase spreads mean?

Question

Patient had cytogenetic analysis on bone marrow with indication of a clonal abnormality. I'm trying to understand the hematopathology report indicating thrombocytopenia and minor megakaryocytic dysplasia. Thank you.

Answer 1

Ignore the first user. I will tell u exactly what it means. It means that there is a very high chance that the thrombocytopenia is due to a clonal bone marrow failure disease called myelodysplasia. The presence of dysplasia (even minor) in the megakaryocytes supports this. Depending upon the severity of thrombocytopenia and the number of blast cells in the bone marrow and the number of other cell lines (RBC, myeloid) affected, your doctor can tell you the prognosis and the treatment. Or u can post it on the internet and i will tell u for free :))

Answer 2

Oh for crying out loud! You are way in over your head and pathologist probably do not answer questions for simple people who are asking these questions on the internet, but hey, at least your making an effort.
Bone marrow biopsy results is way way way over my head and unless you have a degree in pathology, its way over your head to.
I would suggest you take the paper to the doctor and ask him what significance it has to the patient you are reading this on.
People get their medical records expecting to read and understand them, It dont happen. It just leaves the pts confused and lost.
At least you tried to help.