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Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods.

Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly known as Streptomyces erythraeus.

Systematic (IUPAC) name
6-(4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl)oxy-14-ethyl-7,12,13-trihydroxy-
4-(5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl)oxy-3,5,7,9,11,13-hexamethyl- 1-oxacyclotetradecane-2,10-dione

Identifiers
CAS number 114-07-8
ATC code J01FA01
PubChem 3255
DrugBank APRD00953
Chemical data
Formula C37H67NO13
Mol. weight 733.93 g/mol
Pharmacokinetic data
Bioavailability 100%
Protein binding 90%
Metabolism liver (under 5% excreted unchanged)
Half life ?
Excretion bile
Therapeutic considerations
Pregnancy cat. A(AU) B(US)

Legal status ℞ Prescription only

Routes oral, iv, im

2006-08-07 06:42:10 · answer #1 · answered by legalbambino 2 · 0 0

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