If you are not an orphan, and neither of your Parents families had Hemophilia, could you p[possible get it?

Answer 1

Well, you can't GET hemophilia - it's passed on genetically by a carrier mother. Here's how it goes:


How is hemophilia passed on from one generation to the next?


The genes responsible for producing Factor VIII and IX, the mutant genes in hemophilia, are situated on the X chromosome. This makes hemophilia a sex-linked genetic disorder.

Figure 4 shows what happens when a hemophiliac male has a child with a normal female.






All the daughters will be carriers of hemophilia since they must inherit the X chromosome which carries hemophilia from the father. All sons will be unaffected by hemophilia since they inherit the father's normal Y chromosome.

Figure 5 shows the heredity pattern when a normal male has a child with a female carrier of hemophilia.







If they have a son, he has a 50% chance of having hemophilia. This is determined by which X chromosome he inherits. If he inherits the mother's normal X chromosome, the boy will not have hemophilia. If he inherits the mother's mutated X chromosome, he will.

In the same way, the couple's daughter has a 50% chance of being a carrier. She could inherit the mother's normal X chromosome, and be normal herself. On the other hand, she could inherit the mother's X chromosome carrying the hemophilia defect and be a carrier.


Can carriers have hemophilia?


Because carriers have one normal X chromosome which produces a certain amount of Factor VIII or IX clotting factor, they are protected from the most severe form of hemophilia in which the level of clotting factor is less than 1%.

However, the variation in clotting factor levels in carriers is very wide. It ranges from levels similar to those of hemophiliacs in some carriers to normal levels in others. This is because the two X chromosomes, one of which carries the hemophilia gene, are not equally functional. If the hemophilia X chromosome happens to be functional in most cells, then the carrier will have a very low level of clotting factor activity.

Many carriers have a clotting level between 30% and 70% of normal and do not usually suffer from excessive bleeding. However, some carriers have less than 30% of the normal level of Factor VIII or IX. These women are considered to be mild hemophiliacs.

In any case, all carriers should pay close attention to signs of abnormal bleeding. These signs include:


heavy, prolonged menstrual bleeding (menorrhagia)

easy bruising

frequent nose bleeds.

Is there always a history of hemophilia in the family?


No. There are several explanations for a boy being born with hemophilia when there is no history of hemophilia in the family.


Hemophilia does indeed run in the family but there is no evidence of it because no hemophiliac boys have been born in living memory.
The genetic mutation responsible for hemophilia occurred in the mother at the time of her conception. The mother is then the first person in the family to carry hemophilia. Her children could be affected either as carriers or as hemophiliacs.
The mutation occurred at the conception of the hemophiliac child. Either the egg from the mother or the sperm from the father underwent a mutation. In such a case, the mother is not a carrier, and her other children would not be affected by hemophilia.
Figure 6 shows the family pattern when a hemophiliac boy is born to a mother who is not known to be a carrier.






It is estimated that up to 30% of cases of hemophilia have no known family history. Many of these cases are the result of new mutations. This means that hemophilia can affect any family.

Because sisters and mothers of hemophiliacs are not necessarily carriers, as seen in Figures 5 and 6, it is important to do hemophilia carrier testing.

Answer 2

No, But. While most cases of hemophilia are the result of a gene passed throught the mother, there are numerous cases of what is known as spontaneous mutation where the child becomes a carrier and passes on the mutation to her children. The most famous example of spontaneous mutation for hemophilia is Queen Victoria.

Answer 3

Hemophillia is a recessive gene. You need to get one gene for it from both your mother and your father. Since it is recessive, it can be passed down for several generations and untill it meets up with another one, the person will not have hemophilia.

You can't "catch" hemophilia.

Thanks,
Melissa

Answer 4

yup your mother could be a carrier. look back on her line because it's on the x chromosome. and sometimes it's a random mutation