what is tianeptine?

Answer 1

Tianeptine (INN) (Stablon®, Coaxil®, Tatinol®), is an Selective Serotonin Reuptake Enhancer (SSRE), structurally similar to the tricyclic antidepressants. Unlike the tricyclics, however, it enhances the reuptake of serotonin instead of blocking it. No data is available regarding effects of the drug on postsynaptic receptors.

Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, making it particularly suitable for use in elderly patients and in those following alcohol withdrawal as these patients are known to be more sensitive to the adverse effects of psychotropic drugs.

Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with fewer side effects. It was even more effective than maprotiline in a group of patients with coexisting depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas on paroxetine (Paxil) or tianeptine (Stablon) therapy showed equivalent panic-blocking effects.

Tianeptine has been reported to be very effective for asthma starting in August of 1998, when Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracas published the results of a 52-week randomized controlled trial of asthmatic children; the children in the groups that received tianeptine had a sharp decrease in clinical rating and increased lung function.

Two years earlier, they had found a close, positive association between free serotonin in plasma and severity of asthma in symptomatic patients.As tianeptine was the only agent known to reduce both free serotonin in plasma and enhance uptake in platelets, they decided to use it to see if reducing free serotonin levels in plasma would help.By November of 2004, there had been two double-blind placebo-controlled crossover trials, and a 25,000+ patient open-label study lasting over seven years, all showing effectiveness

A 2005 study in Egypt demonstrated tianeptine to be effective in men with depression and erectile dysfunction. Tianeptine is also being studied in the treatment of ADD/ADHD

According to Servier International, tianeptine is contraindicated in children under 15 years of age, people taking MAOIs, and pregnant or lactating women. However, as of 2005, there are no studies published showing increased risk of birth defects.

Side effects
Tianeptine was both studied for short-term (3 month) and long-term treatment (12 months) and equally well tolerated. The studies encompassed 1,300 to nearly 3,000 patients each. Side effects are as follows (Amitriptyline vs Tianeptine):
dry mouth (38 vs 20%)
constipation (19 vs 15%)
dizziness/syncope (23 vs 13%)
drowsiness (17 vs 10%)
postural hypotension (8 vs 3%)
Insomnia and nightmares occur more often in tianeptine than in amitriptyline recipients (7 vs 20%)
Costa e Silva and colleagues at the Jardim Botanico in Rio de Janeiro, Brazil reported a greater frequency of headaches in the tianeptine group as compared with placebo
So far neither seizures nor kidney or bone marrow damage have been noted.
Liver toxicity has been observed very rarely, as is the case with amineptine, however, this is thought to be due to genetic predisposition and is often preceded by rash, itching, fever, and/or abdominal pain.

Although Servier's official recommendation is 12.5mg three times per day before the main meals of the day, lower or higher doses may be used as determined by your prescribing physician

As is generally true for activating/nonsedating antidepressants, particularly agitated patients or those developing increase of energy together with suicidal thoughts before remission occurs will normally need initial comedication (1 to 4 weeks) with an effective sedating drug such as a benzodiazepine or the neuroleptic chlorprothixene. Additionally, hospitalisation of these patients is desirable (close observation possible). These measures to lower the risk of suicide should be continued until remission of depression is stable

Answer 2

Tianeptine is a Selective Serotonin Reuptake Enhancer (SSRE), structurally similar to the tricyclic antidepressants. Unlike the tricyclics, however, it enhances the reuptake of serotonin instead of blocking it. No data is available regarding effects of the drug on postsynaptic receptors.

Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, making it particularly suitable for use in elderly patients and in those following alcohol withdrawal as these patients are known to be more sensitive to the adverse effects of psychotropic drugs.

Currently, tianeptine is approved in France. The manufacturer there is Servier. It is also marketed to a host of countries in Europe, Asia and Latin America.

Answer 3

avolition and flattened affect are just symptoms that point to the diagnosis of schizophrenia you cannot explain them by the diagnosis everyone experiences their sschizophrenia differently nad you are welcome to think this is at the heart of your own problems but the diagnosis is only made if you tick so many boxes and as you point out your symptoms could be also down to bi-polar dx - Its a bit like wanting to know which bean you ate made you trump and you will go round in circles and basically no one knows - a good piece of work to read is about early psychiatry called human traces by sebastien ffaulkes which might give you an idea about how little we really know about any mental disorder

Answer 4

Tianeptine is an antidepressant that is chemically related to amineptine. It is a serotonin reuptake accelerator and works opposite to the action of SSRI's.

Answer 5

Go to www.encyclopedia.thefreedictionary.com/tianeptine

Answer 6

antidepressant,Drug to minimize function of certain parts of body,likes nervous system,for those having depression-psychcological problems-related to works,family and social, causes emotional pain-sufferings,declining productiveity,family relationships,

Answer 7

never heard of it,is it catching,give us a clue what is it

Answer 8

http://www.tianeptine.org/