L-Histidine?

Question

Does anyone know about L-Histidine? Does it really help with stomach problems?

Answer 1

Histidine is one of the 20 most common natural amino acids present in proteins. In the nutritional sense, in humans, histidine is considered an essential amino acid, but mostly only in children. The imidazole side chains and the relatively neutral pK of histidine (ca 6.0) mean that relatively small shifts in cellular pH will change its charge. For this reason, this amino acid side chain finds its way into considerable use as a co-ordinating ligand in metalloproteins, and also as a catalytic site in certain enzymes. The imidazole side chain has two nitrogens with different properties: One is bound to hydrogen and donates its lone pair to the aromatic ring and as such is slighty acidic, whereas the other one donates only one electron to the ring so it has a free lone pair and is basic. These properties are exploited in different ways in proteins. In catalytic triads, the basic nitrogen of histidine is used to abstract a proton from serine, threonine or cysteine to activate it as a nucleophile. In a histidine proton shuttle, histidine is used to quickly shuttle protons, it can do this by abstracting a proton with its basic nitrogen to make a positively-charged intermediate and then use another molecule, a buffer, to extract the proton from its acidic nitrogen. In carbonic anhydrases, a histidine proton shuttle is utilized to rapidly shuttle protons away from a zinc-bound water molecule to quickly regenerate the active form of the enzyme.

The amino acid is a precursor for histamine and carnosine biosynthesis.

There are two enantiomers: D-histidine and L-histidine.

Answer 2

yes it probably does help. it has been know to reduce stomach acid the research is more than 15 years old personally never try it because it has been hard find i think it was 1986 the first time i herd about this. Other things that are helpful are licorice root (good for stomach irritation or intestinal the bad thing is that it can raise blood pressure in some people ) , European centaury (in the botanical literature is said to reduce stomach acid also ) also helps but is hard to find at least the real one

Answer 3

Here is a site that has anything about any medications, weather it is prescription or over the counter. It is through the government, the national library of medicine and the national institute of health.

http://www.nlm.nih.gov/medlineplus/drugsinformation.html

Answer 4

ask your doctor better yet your pharmacist