What is the significance of LSB and MSB?

Question

LSB - Low significant byte
MSB - Most significant byte

Answer 1

The most significant bit (MSB) is the bit in a multiple-bit binary number with the largest value. This is usually the bit farthest to the left, or the bit transmitted first in a sequence. For example, in the binary number 1000, the MSB is 1, and in the binary number 0111, the MSB is 0.

When the MSB in a sequence is farthest to the left (or first), the least significant bit or byte (LSB) is usually the one farthest to the right (or last). In this case, the sequence is said to be big-endian. If the order is reversed so the MSB is farthest to the right (or last) and the LSB is farthest to the left (or first), the sequence is said to be little-endian.