what is anti-AB serum? What is its significance in blood test? How is it significant in bombay phenotype?

Answer 1

A rare genotype (blood group) of people was detected in Mumbai, a few decades back, who neither had A, AB, B or O group of blood. This rare genotype was labelled as the Bombay Blood Group. If a Bombay Blood Group recipient is not transfused the blood of the same group he can die of a haemolytic transfusion reaction occurring as a result of immediate red cell lysis because of the presence of anti H antibodies in the serum of Bombay Blood Group patients. Studies reveal that this is due to the absence of the H substance (antigen) in the red cells. The absence of the H substance is attributed to the deficiency of the enzyme fucosyl transferase. The Bombay Blood Group phenotypes lack H antigen in the red cells and have anti-H in the serum.

Family studies have shown that the Bombay phenotype, called as Oh, is due to the presence in homozygous state of a rare recessive gene. The precursor protein from which the blood group proteins are formed is termed as the H substance. This is bio-chemically produceA rare genotype (blood group) of people was detected in Mumbai, a few decades back, who neither had A, AB, B or O group of blood. This rare genotype was labelled as the Bombay Blood Group. If a Bombay Blood Group recipient is not transfused the blood of the same group he can die of a haemolytic transfusion reaction occurring as a result of immediate red cell lysis because of the presence of anti H antibodies in the serum of Bombay Blood Group patients. Studies reveal that this is due to the absence of the H substance (antigen) in the red cells. The absence of the H substance is attributed to the deficiency of the enzyme fucosyl transferase. The Bombay Blood Group phenotypes lack H antigen in the red cells and have anti-H in the serum.

Family studies have shown that the Bombay phenotype, called as Oh, is due to the presence in homozygous state of a rare recessive gene. The precursor protein from which the blood group proteins are formed is termed as the H substance. This is bio-chemically produced.
Experts say that if proper blood grouping or testing practices is not followed, it can lead to people with Bombay blood group not being detected. According to Dr Mukesh Desai, during cell grouping or routine grouping, Bombay Blood Group would be categorised as O group because they wouldn’t show any reaction to anti-A and anti-B antibodies just like a normal O group. When a cross matching with different blood bags of O group is done, then it would show cross-reactivity or incompatibility. Therefore reverse grouping or Serum grouping has to be performed to detect the Bombay Blood group.

Other issues related to Bombay Blood Group are that blood is incompatible with all A, B and O donors. In routine forward grouping, this blood group would give reaction as an ’O’ blood group where as in serum grouping it would show reaction with ’O’ cells due to the presence of anti H in their serum. Once detected, are registered at Institute of Immuno-haematology (IIH)) for further studies as well as for availability of information regarding the donors of this group.

Answer 2

i became an identical way with my first being pregnant. i became a lot greater fearful of the needles than of giving start. I cried all the way by my first blood try to particular it harm yet no longer almost as undesirable as i had concept it would (besides the undeniable fact that I nevertheless cry while i comprehend I could desire to have blood drawn). The tension is particularly worse than the technique. Ask for a butterfly needle (what they use on infants) they harm way much less. additionally do no longer seem. It looks like a sharp sting that lasts purely a 2d or 2 and then basically form of an uncomfortable feeling while the needle is on your arm, back much less uncomfortable with a butterfly needle. good success!