what is valpronic acid ? what minimum quantity is required in blood ? what is the natural source of this ?

Question

where it is manufactred in body. What will happen to if it is low or higher is blood from normal level

Answer 1

Do you mean valproic acid?

Valproic acid is made from sodium valproate and is used in the treatment of epilepsy and bipolar disorder. It is thought to block the degradation of the molecule GABA, which is important in suppressing the activity of neurons. By increasing GABA concentrations valproic acid decreases the chance of seizures, and reduces the manic phase of manic depression (bipolar disorder).

Sodium valproate is synthesized in the laboratory. I don't know of any natural sources for it.

Answer 2

As far as I know there's no quantity produced naturally by our body..The Valpronic acid is one of the most powerful substances ,which is anti-epileptic,and is usually prescribed by neurologist to treat and "cure" epylepsy.The most common prescribed medication is called Depakin and contain 500 or 1000 mg of Valpronic acid..

Answer 3

If you are referring to valproic acid, my husband was just prescribed it to treat depression (or so the doctor claimed) after a week, i found him huddled in a dark corner, shaking & sobbing like the world was going to end, because he couldn't figure out what to fix for dinner.
It didn't take long for me to get the doctor to take him off of that stuff.

Answer 4

VALPROIC ACID

PRODUCT IDENTIFICATION
CAS NO. 99-66-1

VALPROIC ACID
EINECS NO. 202-777-3
FORMULA (CH3CH2CH2)2CHCOOH
MOL WT. 144.21

H.S. CODE

TOXICITY
Oral rat LD50: 670 mg/kg

SYNONYMS 2-Propyl-Valeric acid; Dipropyl-Acetic acid; 2-Propylpentanoic acid; 2-Propylpentanoic acid; 2-Propylvaleric acid; Di-n-dipropylacetic acid; Acido valproico; Depakine; Depakote; Di-n-propylacetic acid; Di-n-propylessigsaure; Dipropylacetic acid; Kyselina 2-propylvalerova; Mylproin; n-Dipropylacetic acid;

DERIVATION

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE clear liquid
MELTING POINT 120 - 130 C
BOLING POINT 220 C
SPECIFIC GRAVITY 0.907
SOLUBILITY IN WATER slightly soluble

SOLVENT SOLUBILITY
Very soluble in Organic solvents

pH

VAPOR DENSITY
4.97

AUTOIGNITION

NFPA RATINGS


REFRACTIVE INDEX
1.4250

FLASH POINT
111 C

STABILITY Stable under ordinary conditions.

APPLICATIONS
Valproic acid and its derivatives are used solely or in combination with other anticonvulsants to prevent seizures and migraines. Valproates are effective against the manic phase of bipolar disorder.

SALES SPECIFICATION

APPEARANCE
Clear liquid

CONTENT
98.0% min

TRANSPORTATION PACKING
20 KG per bucket

HAZARD CLASS 8 (Packing Group: III)
UN NO. 3265

GENERAL DESCRIPTION OF CARBOXYLIC ACID
Carboxylic acid is an organic compound whose molecules contain carboxyl group and have the condensed chemical formula R-C(=O)-OH in which a carbon atom is bonded to an oxygen atom by a double bond and to a hydroxyl group by a single bond), where R is a hydrogen atom, an alkyl group, or an aryl group. Carboxylic acids can be synthesized if aldehyde is oxidized. Aldehyde can be obtained by oxidation of primary alcohol. Accordingly, carboxylic acid can be obtained by complete oxidation of primary alcohol. A variety of Carboxylic acids are abundant in nature and many carboxylic acids have their own trivial names. Examples are shown in table. In substitutive nomenclature, their names are formed by adding -oic acid' as the suffix to the name of the parent compound. The first character of carboxylic acid is acidity due to dissociation into H+ cations and RCOO- anions in aqueous solution. The two oxygen atoms are electronegatively charged and the hydrogen of a carboxyl group can be easily removed. The presence of electronegative groups next to the carboxylic group increases the acidity. For example, trichloroacetic acid is a stronger acid than acetic acid. Carboxylic acid is useful as a parent material to prepare many chemical derivatives due to the weak acidity of the hydroxyl hydrogen or due to the difference in electronegativity between carbon and oxygen. The easy dissociation of the hydroxyl oxygen-hydrogen provide reactions to form an ester with an alcohol and to form a water-soluble salt with an alkali. Almost infinite esters are formed through condensation reaction called esterification between carboxylic acid and alcohol, which produces water. The second reaction theory is the addition of electrons to the electron-deficient carbon atom of the carboxyl group. One more theory is decarboxylation (removal of carbon dioxide form carboxyl group). Carboxylic acids are used to synthesize acyl halides and acid anhydrides which are generally not target compounds. They are used as intermediates for the synthesis esters and amides, important derivatives from carboxylic acid in biochemistry as well as in industrial fields. There are almost infinite esters obtained from carboxylic acids. Esters are formed by removal of water from an acid and an alcohol. Carboxylic acid esters are used as in a variety of direct and indirect applications. Lower chain esters are used as flavouring base materials, plasticizers, solvent carriers and coupling agents. Higher chain compounds are used as components in metalworking fluids, surfactants, lubricants, detergents, oiling agents, emulsifiers, wetting agents textile treatments and emollients, They are also used as intermediates for the manufacture of a variety of target compounds. The almost infinite esters provide a wide range of viscosity, specific gravity, vapor pressure, boiling point, and other physical and chemical properties for the proper application selections. Amides are formed from the reaction of a carboxylic acids with an amine. Carboxylic acid's reaction to link amino acids is wide in nature to form proteins (amide), the principal constituents of the protoplasm of all cells. Polyamide is a polymer containing repeated amide groups such as various kinds of nylon and polyacrylamides. Carboxylic acid are in our lives.