What is the risk factor ratio associated with Edward's syndrome for Indian women over 35?

Question

Prefer India norms as we live abroad and the risk factor given to us is for this country

Answer 1

Edward's Syndrome is caused by having 3 copies - instead of 2 copies - of chromosome 18. This usually occurs before conception. I do not think it is possible for an adult to suddenly get Edward's Syndrome, at any age. The rate of occurrence for Edward's Syndrome is ~ 1 : 3000 conceptions. Although women in their 20's and 30's can conceive Edward's Syndrome babies, there is an increased risk as the woman's age increases.