25 years old. I have over active bladder??

Question

I have had pressure in my lower abdomen for the past 2 years. I would have a strong urge to pee & could barely go because I go so often (like 15 times a day.)( I was tested for UTI several times which was always negative.) Immediantly the urge & pressure would be back ...knowing I didn't have to go. My gynocologist put me on Detrol-La and my symptoms were completely gone after a few weeks!!!!! Yea!!! I can't believe I suffered for so long.

My question is what causes over active bladder? And why would I have it at 25? I've never been pregnant & am otherwise very healthy. Thanks.

Answer 1

My advice would be to see your gynecologist and have he/she check your uterus. Sometimes a prolapsed uterus can put pressure on the bladder and cause the symptoms you describe.

Answer 2

Lasix is a diuretic and only works on the kidneys (on a very specific site in the nephrons). It makes your kidneys dump out water and some salts.

Detrol LA is used for bladder dysfunction. There are two kinds of bladder dysfunction. Since you're using detrol, I am assuming that you have a small, failure-to-store bladder (overactive bladder). Meaning, that your bladder is constantly contracting so it's not able to store and hold urine. Detrol relaxes the bladder muscles so that it can hold more urine.

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As you can see, the sites of action are quite different. And their metabolisms do not not effect each other (how the body chemically changes the drugs). However, since the lasix is making more urine- your bladder may/may not be able to hold it or its just full from it. If they are off-setting each other, that's probably where its happening.

Here are some suggestions:
1. take your lasix in the morning and your detrol at night
2. Detrol LA is only taken once a day- maybe ask your doctor to try regular detrol which is taken twice a day. You may get a higher concentration with the regular release (note: detrol has lots of side effects so either read your pamphlet that came with your prescription or ask your pharmacist)
3. Place all your prescriptions/supplements/herbals in a bag and take it to your pharmacist. Ask him to look for CYP450 2D6 and 3A4 and cholinergic interactions (he'll know what those mean). Those kinds of interactions will definitely off-set your Detrol.
4. Ask your doctor about possibly trying Ditropan (regular or XL) instead of Detrol

Answer 3

I'm a male and had the same problem I lossed control of my bladder the one day.i have a question for you do you drink things like flavored waters ie propel? My problem stemmed from the one preservative used in drinks like that it's called sodium hexametaphosphate it causes calcium deposits to form along the urethra and can also cause kidney stones but I would still tell you to see a doctor. Hope this helped :)