How is human personality coded in DNA?

Question

DNA codes for proteins ONLY. Keeping that in mind, how is aspects such as personality, a very conceptual matter, "coded" by something of a (dear I say) "tangible" element such as DNA? So, does proteins direct our personality? If so, how?

Answer 1

Hi positive! One mechanism where protein function (and therefore the genetic makeup that dictates the structure/function of that protein) can affect personality is via cell membrane receptors (especially receptors for neurotransmitters).

Genetic variation via Single Nucleotide Polymorphisms (SNiPs) can impact on the efficiency of the response of cellular receptors (which are proteins) to their endogenous signaling molecules (e.g. neurotransmitters, hormones, neuromodulators, etc.).

Another mechanism would be the impact a genetic variation might have on the ability to detoxify a signaling molecule (again, a neurotransmitter, hormone, etc.). SNiPs in detoxification enzymes (e.g. COMT - Catechol - O - Methyl - Transferase, MAO - Mono Amine Oxidase, Cytochrome P450 enzymes, etc.) can lead to slower or more rapid removal of signaling molecules that affect brain function/affect and thus, personality.

Frankly, your question sounds like an excellent topic for a Ph.D. thesis!

Hope you find this helpful. Best wishes and good luck.

Answer 2

A simple example would be the neurological sense. For instance, proteins developed via DNA code for the development of unsatisfactory neurotransmitters or their receptors. This could cause an imbalance in chemicals that would give you a short temper, depression, etc. by preventing to develop the necessary means for you to balance and control the neurotransmitters in general. Of course, this is just one example.

Answer 3

It is not, personality development is entirely environmental.

Answer 4

It's not.