Astronauts who spend long periods in outer space could be adversely affected by weightlessness?

Question

Astronauts who spend long periods in outer space could be adversely affected by weightlessness. One way to simulate gravity is to shape the spaceship like a bicycle wheel that rotates about an axis just like a wheel, with the astronauts walking on the inside of the "tire."
Consider
a) how objects fall
b) the force we feel on our feet
c) any other aspects of gravity you can think of.

Please help, thank you!

Answer 1

(A) Objects float to the center of gravity.
(B) Ever been on a Boat?
(C) With a low force of gravity a person become extremely large.