Do you feel tiny and insignificant?

Answer 1

Not at all, because being a tiny part of a greater civilization is not metaphysically important--you have to live somewhere. What is important is that you are one of a kind, and your uniqueness should make you feel very significant--if you use it wisely to your own reasonable advantage.
If you let yourself get "lost in the shuffle," then you lose your uniqueness, and you would then deserve to feel insignificant. But at that point, you can still regain your significance by stepping out of the "shuffle" and get back to being uniquely you.

Answer 2

When we look at the cosmos, we feel that we are
very tiny compared to it. The Hindu Upanishads
say that every thing in creation, including a single
cell living being and a sand particle, is a microcosm.
The more you learn about even such small things,
you will come to know that there is more to learn.