allosteric regulation?

Question

can someone please explain what is it and how does it work? S:

Answer 1

Allsoteric regulation can be seen in enzymes that are supposed to be allosteric molecules. The binding of a molecule at point affects the geometry of the enzyme in such a way that the geometry of active site is influenced and vice versa.Many enzymes have two sites: active site and allosteric site where a cofactor or other molecule binds.
In allosteric regulation the end product of a biochemical pathway may bind the allosteric site of the enzyme of another pathway to either inactivate or activate it.

Answer 2

Allosteric regulation is when a molecule binds to an enzyme in a place other than the active site, inducing a change that either increases or decreases the enzyme's activity.

For example, phosphofructokinase is an enzyme in the pathway that breaks down glucose in your body to ultimately make ATP. If you have a sufficient level of ATP in the cell, the ATP will bind allosterically to the enzyme and inhibit it. That makes sense for it to do that because you don't want to break down more glucose if you already have enough ATP to begin with.

In fact, ATP is a POSITIVE regulator of some enzymes in the pathway that stores glucose away as glycogen. If you already have enough ATP, then you want to store the glucose rather than break more if it down.

make sense?