relationship between genome and proteome...?

Question

Describe the relationship between the genome and one of your liver cells and the genome of one of your muscle cells. Describe the relationship between the proteome of one of your muscle cells and the proteome of one of your liver cells.

Answer 1

All your cells (hopefully) have all the same genome. At one point you were one cell each division exactly duplicated the DNA in that one cell, so all cell have the same DNA, the same genes, and the same genome.

BUT all cells do not USE all the same genes, starting almost from the first division. Some are just not activated, some are almost permanently blocked, and gradations in between. Since genes that are not in use do not produce proteins, we can expect mucles and liver cells to have some substantial differences between the proteins they produce.

Their proteomes won't be completely divergent - they do, after all, both have some of the same basic needs - but mucle cells need to be packed with myofibrils while liver cells need to secrete bile and store glycogen.