Do phenols react with carboxylic acids to form esters? If not, then why not?Thanks!
2007-09-06 05:48:10 · 3 answers · asked by Muneeb 1 in Science & Mathematics ➔ Chemistry
Yes you can but you need to activate the acid by forming the acid chloride or using one of many carbodiimide coupling agents along with a catalytic amount of N,N-dimethylaminopyridine.
2007-09-06 06:11:47 · answer #1 · answered by Anonymous · 0⤊ 0⤋
The reaction of phenols with carboxylic acids is not very successful, and certainly not in the presence of base. They are not nucleophilic enough.
The best way of making an ester of a phenol is to use an acid chloride (acyl chloride) or anhydride instead of the acid.
2007-09-06 06:00:41 · answer #2 · answered by Gervald F 7 · 0⤊ 0⤋
H2CO3 + NaOH = NaHCO3 + H2O benzoic acid + NaOH = NaC7H5O2 + H2O NaHCO3 + benzoic acid = NaC7H5O + H2O + CO2 Phenol is an alcohol, it does not have a -COOH group, only an -OH group. If this it would react, the covalent bonds would be not correct.
2016-04-03 06:48:09 · answer #3 · answered by ? 4 · 0⤊ 0⤋