Is anyone aware of a chihuahua mating with an irish wolfhound?

Answer 1

I remember seeing something similar on a rescue site once.. the pup had to be put down.. the organs were too large for the body.. or vice versa.. I'll try digging up a link, but it was at least a year ago that I read it..

Answer 2

Hypothetically possible but probably not. If the chihuahua is a female, she would not physically be able to carry the puppies to term.