How far between Luxembourg and Geneva? Is it bike-able by a non tour de Francer over a week?

Answer 1

There are long distance bike trails and tour guides.

I am looking for some links for you, here is one links page with a lot of links to sites:
http://www.kenkifer.com/bikepages/links/linktome.htm#Travel
A site with links to actual journey stories:
http://www.humanpowered.org/default.view
I also found a page mentioning Luxembourg and Geneva, I have not read the site but it seems like he has traveled through them during a longer trip:
http://www.geocities.com/glenn_ord/europe.html

If you do a search yourself you will be able to find more.
Or join a forum on one of the bike sites and ask.

Answer 2

Here some basic information :
Distance is about 500 km.
http://www.camino10.com/index.htm