Can you take SAMe and St. Johns Wort simultaneously?

Answer 1

Sure. They both work for different aspects of mood and there are no interactions, so there is no problem

More specifically, SAMe helps with neurotransmitter production and St. John's Wart is simply for "emotional wellness".

As long as you go by the warnings on the bottles, you'll be fine. St. John's Wart specifies that it may cause the skin and eyes to become photosensitive, so you should avoid tanning beds and being out in the sun too long. They both specify not to take if you're pregnant or nursing and to consult a doctor if you are taking any prescriptions or if you have any medical conditions (which are common warnings).