My brother has hemophilia, what is the odd for my children having this deases if I marry my boy friend?

Question

My boy friend who am planning to marry has no history of hemophilia in his family.

Answer 1

Maybe you are unaware, but Hemophilia is called the "Royal Disease" because members of the Royal Family (Great Britain) passed it down. You carry the gene already, since your brother has Hemophilia. Females pass on this disorder because it is recessive linked. You do not say if he has Type 1 or Type 2. If he still has it as an adult, it is Type 1.
1/4000 males worldwide have Hemophilia.There is an abnormality in Gene F8 on the X chromosome, the blood has the inability to clot. Fortunately, a lot more is known today about this disease, medicines, and your children should be able to live normal lives w/ precautions.

Answer 2

Hemophilia is caused by a recessive gene on the X chromosome. Since your mother would have had one hemophiliac gene and one normal gene the odds of you being a carrier are 50/50.

If you are a carrier and you have a son the odds of him having hemophilia are 50/50.

If you have a daughter she will be fine, but the odds are 50/50 she will be another carrier, as you are.

Answer 3

Even if you do not show the symptoms of haemophilia, you could still be a possible carrier.

Haemophilia is found on the X chromosome.
Let's say your boyfriend is: XY (Normal, male)
and you are: X'X (Carrier, female).

Possible gametes:

___X____Y

X'_X'X__X'Y

X_XX___XY

This shows that there is a 1:1:1:1 ratio probability.
There is 25% chance the child will be normal, female.
There is 25% chance the child will be normal, male.
There is 25% chance the child will be carrier, female.
There is 25% chance the child will be haemophilic, male.

Here is also an excellent diagram to show the probabilities IF you are a carrier:

http://upload.wikimedia.org/wikipedia/commons/a/a3/XlinkRecessive.jpg

Being a carrier is when a FEMALE only has only ONE gene for haemophilia. This means that the female would need X'X' to be haemophilic. Males cannot be carriers.

Answer 4

Noone here can say because we do not know if you are a carrier or not, and we also do not know if you will fall head over heals in love with a hemophiliac male. If you are really concerened about this (and in my opinion you should be) see a genetic counselor with the father to be prior to attemping to have children, they will do testing and let you know what your risks are for a number of genetic disorders, not just hemophilia.

Answer 5

You have a 50% chance of having a girl, and that girl will have a 0% chance of having hemophila.

You have a 50% chance of having a boy, and that bot will have a 50% chance of getting hemophilia.

So as a whole there is a 50% chance that you will have a child whith hemophilia.