Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae), predominantly in tobacco, and in lower quantities in tomato, potato, eggplant (aubergine), and green pepper. Nicotine alkaloids are also found in the leaves of the coca plant. Nicotine constitutes 0.3 to 5% of the tobacco plant by dry weight, with biosynthesis taking place in the roots, and accumulating in the leaves. It is a potent neurotoxin with particular specificity to insects; therefore nicotine was widely used as an insecticide in the past, and currently nicotine derivatives such as imidacloprid continue to be widely used.
In low concentrations (an average cigarette yields about 1mg of absorbed nicotine), the substance acts as a stimulant in mammals and is one of the main factors responsible for the dependence-forming properties of tobacco smoking. According to the American Heart Association, "Nicotine addiction has historically been one of the hardest addictions to break." Nicotine is one of the most addictive substances known to man. In heavy smokers, the addiction can be comparable to the extremely potent drugs cocaine, and even heroin in terms of addiction intensity.[1]
History and name
Nicotine is named after the tobacco plant Nicotiana tabacum, which in turn is named after Jean Nicot, a French ambassador, who sent tobacco and seeds from Portugal to Paris in 1550 and promoted their medicinal use. Nicotine was first isolated from the tobacco plant in 1828 by German chemists Posselt & Reimann. Its chemical empirical formula was described by Melsens in 1843, and it was first synthesized by A. Pictet and Crepieux in 1893.
2007-07-20 00:14:04
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answer #4
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answered by sagarukin 4
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Synonyms:
(+-) NICOTINE, (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine, (+-)-Nicotine, (-)-3-(1-Methyl-2-pyrrolidyl)pyridine, (-)-Nicotine, (RS)-Nicotine, (R,S)-Nicotine, (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine, (S)-3-(1-methylpyrrolidin-2-yl)pyridine, (S)-Nicotine, .beta.-Pyridyl-.alpha.-N-methylpyrrolidine, 1-methyl-2-(3-pyridal)-pyrrolidene, 1-Methyl-2-(3-pyridyl)pyrrolidine, 13890-81-8, 13890-82-9, 16760-37-5, 22083-74-5, 3-(1-Methyl-2-pyrrolidinyl)pyridine, 3-(N-Methylpyrollidino)pyridine, 3-(N-Methylpyrrolidino)pyridine, 3-(tetrahydro-1-methyl pyrrol-2-yl)Pyridine, 5-23-06-00064 (Beilstein Handbook Reference), 54-11-5, 551-13-3, 6912-85-2, AI3-03424, beta-Pyridyl-alpha-N-methylpyrrolidine, Black Leaf, Black Leaf 40, BRN 0082111, c0468, Caswell No. 597, CCRIS 1637, destruxol, Destruxol orchid spray, DL-tetrahydronicotyrine, EINECS 200-193-3, Emo-Nik, ENT 3,424, EPA Pesticide Chemical Code 056702, Flux Maag, Flux Maay, fumeto bac, Fumetobac, Habitrol, HSDB 1107, L-3-(1-Methyl-2-pyrrolidyl)pyridine, L-Nicotine, Mach-Nic, methyl-2-pyrrolidinyl)pyridine, Micotine, niagara p.a., Niagara p.a. dust, Nic-Sal, Nico-Dust, Nico-Fume, Nicocide, Nicotin, Nicotina, Nicotina [Italian], NICOTINE, Nicotine alkaloid, Nicotine and salts, Nicotine [BSI:ISO], Nicotine [UN1654] [Poison], Nicotine [USAN], Nicotine, (+-)-, Nicotine, liquid, Nicotrol, Nicotrol Inhaler, Nicotrol NS, Nikotin, Nikotin [German], Nikotyna, Nikotyna [Polish], NSC 5065, NSC5065, Ortho N-4, Ortho N-4 and N-5 dusts, Ortho N-4 dust, Ortho N-5, Ortho N-5 dust, Prostep, Pyridine, 3- (1-methyl-2-pyrrolidinyl)-, (S)-, Pyridine, 3- (tetrahydro-1-methylpyrrol-2-yl), Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, Pyridine, 3-(1-methyl-2-pyrrolidinyl)- (9CI), Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)- (9CI), Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl), Pyrrolidine, 1-methyl-2-(3-pyridal)-, RCRA waste no. P075, RCRA waste number P075, S-(-)-Nicotine, Tendust, Tetrahydronicotyrine, DL-, UN1654, XL All Insecti-cide, Emo-Nib, XL All Insecticide
2007-07-19 23:55:28
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answer #6
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answered by jarynth4 1
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