What is the wobble hypothesis?

Answer 1

In 1966, Francis Crick proposed the Wobble hypothesis. He suggested that while the interaction between the codon in the mRNA and the anticodon in the tRNA needed to be exact in two of the three nucleotide positions, this did not have to be so in the third position. He proposed that non-standard base-pairing might occur between the nucleotide base in the 5' position of the anticodon and the 3' position of the codon.

This hypothesis not only accounts for the number of tRNAs that are observed, it also accounts for the degeneracy that is observed in the Genetic Code. The degenerate base is that in the wobble position.

Answer 2

Wobble Hypothesis

Answer 3

-The process by which a single tRNA can decode more than one codon.

The "wobble hypothesis" was proposed by Francis Crick in 1966 as an explanation for how one transfer RNA (tRNA) can recognize two codons.

According to the hypothesis, each tRNA has an anticodon that is a base triplet, and normal base-pairing occurs between the first two bases and complimentary bases in an mRNA codon; the third base has a free play (wobble) that lets it pair with any of a number of bases that are in the third position of different codons.

Answer 4

The wobble hypothesis states that pairing of codon and anticodon follows the normal A-U and G-C rules for the first two base positions in a codon, but that exceptional "wobbles" occur at the third position and that G-U base pairs can also be used.

Answer 5

Define Wobbly

Answer 6

The "Wobble Hypothesis,"discovered by Frances Crick, states that rules of base pairing are relaxed at the third position, so that a base can pair with more than one complementary base. Some tRNA anticodons have Inosine at the third position.

Answer 7

Wobble hypothesis states that during translation, if the 3rd part of the codon is changed it is less likely that it will effect the protein that is produced.