Questions about Haemophilia? Detailed, but not too long, and boring answers please.?

Question

1) Does Haemophilia affect both men and women? Explain.

2) How many people have the condition in the UK alone?

3) Which chrocmosone carries the haemophilia gene?

4) How are haemophiliacs treated?

5) What has genetic engineering done to help haemophiliacs?

Thanks,
Amy xx

Answer 1

Hi Amy

Two of my sons have severe haemophilia type A so I have lived with this condition for quite some time now.
1 Haemophilia is only carried by the female and for every son a female carrier has he has a 50/50 chance of being a haemophiliac, it is usually an inherited condition but in our case it was what they call a spontainious mutation which must of started in myself. As a matter of interest when my sons have children of their own all of their daughters will be carriers of this condition but none of their sons will have it as I said only women carry the disease.

2 Sorry I can't help with that I am from the South of Ireland
3 It is carried on the x chromosone

4 both of my sons are treated differently my eldest son is 12 and he is on what they call treatment on demand when he has a bleed I inject him with factor 8 into a vein. my other son is on what they call profolaxus,he has a portocath small devise fitted into his chest and I inject him into this 3 times a week. They both have the same level of severe haemophilia but for some unknown reason my ten year old bleeds a lot more than my 12 year old.

5 Well at the moment my sons are on a product called Advate and genetic engineering has made it possible that no human blood products have been used in the manufacture of the drug which is a fantastic scientific breakthrough and research is still ongoing who knows what future breakthrough there will be in.
Well Amy hope I havn't bored you too much I tried to keep it short good luck with your research.

Answer 2

1) Does Haemophilia affect both men and women? Explain.
Nearly all affected individuals are male, rarly females. It is X-linked recessive, which means that it affects males much more frequently than females.

2) How many people have the condition in the UK alone?
unsure

3) Which chrocmosone carries the haemophilia gene?
The X-chromosome

4) How are haemophiliacs treated?
with a protein called "factor VIII"

5) What has genetic engineering done to help haemophiliacs?
factor VIII used to be extracted from human blood. It takes blood from many donors to make just one dose of the extract. This increased the risk of becoming infected with a blood borne disease, like HIV.
Genetic engineers have now taken the gene that codes for Human factor VIII, and inserted it into a bacteria. The bacteria now produces the needed protein. Now the risk of infection is basically zero.

Answer 3

1) Both men abnd women. It is inherited through the woman. The children and grandchildren of Queen Victoria.

2) Inquire of the NHS

3) X

4) By injections of Factor VIII of the blood clotting system.

5) Nothing. Little is known. It would be unethical to experiment.

Answer 4

From what I read of the Royal family I think the women are carriers but it actually shows up in the males.

Answer 5

1. No it is xlinked
2. Dunno
3. X
4. Careful not to cut
5. Nothing yet

Answer 6

http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=0&contentid=1

Short enough for you?