what is the best hotel to stay at in barcelona that gives you access to the main sites?

Question

My wife and I want to find a nice hotel that is centrally located that gives us the chance to explore the city, eat great food, drink great wine and just enjoy the city.

Answer 1

We did exactly that and we wrote about it in our travelogue:
http://www.thetravelzine.com/Barcelona2006.htm

Hope that helps!