How does penicillin, the world’s first antibiotic, affects bacterial cells. Plz...Expalin?

Question

Thank You for your answers in advance!!

isranirockstar

Answer 1

Natural penicillin ( V & G ) are effective against several gram - positive bacteria, They inhibit the bacterial cell wall i.e., peptoglycan, synthesis and cause cell death.

Natural penicillians are ineffective against microorganisms that produce bita - lactamase, since this enzyme can hydrolyse penicillins eg. Staphylococcus aureus. Several semi synthetic penicillins that are ressisstant to bita - lactamase have been developed and successfully used against a large number of Gram - negative bacteria. Cloxacillin, ampicillin, flpxacillin and azlocillin are some examples of semi-synthetic penicilins.

From the huge quantities of penicillins produced by fermentation, about 40% are used for human healthcare, 15% for animal health care, and 45% for the preparation of semi-synthetic penicillins.

Answer 2

This site says that penicillin interferes with the formation of the cell wall.

http://www.cellsalive.com/pen.htm