I did it!! It's FINALLY finished!! Are you proud of me??!!?

Question

I finished a 10 page genetics research paper on the molecular basis of Androgen Insensitivity Syndrome or what leads to testicular feminization. I even found the molecular basis of the mutation in the androgen receptor gene!! Sorry I know many of you won't have a clue as to what I'm talking about, but it's a big deal to me. This is what leads to intersexed conditions or "hermaphroditic" people and birth defects of the genitals. YAAAAY!!! I'm proud of me, are you?

Rollthedice....no sorry, no such luck for a CURE, but what I've found in my research is that there is possibly a molecular basis that leads to intersexed conditions, and well, it's kind of hard to explain, but see, in males, androgens like testosterone are made in the testes. This testosterone gets kinda "sucked up" if you will, by something called the androgen receptor, or AR gene. If that AR gene is "broken" then you can't use testosterone or at least not in the quantitities you should be. If an AR gene doesn't work, then it also can't produce mullerian duct hormone which makes male reproductive organs, and what you end up getting is someone that looks totally female on the outside but still has the male, XY chromosome.
Anyway, there's a mututation in the AR gene that causes this. The AR gene has 3 main domains. The DNA-binding domain, the ligand-activated domain, and the transactivation domain. In the transactivation domain (I think) is where the amino acids are formed

and sometimes a repeat of CAG or gluatamine is made here. They've found that an "average" length of this CAG is around 22 base pairs. People with shortened CAG can lead to certain neurological defects, and lengthened CAG can lead to increased androgen action and can lead to an early incidence of prostate cancer and breast cancer in women too.

Answer 1

I know what that is and I'm proud of you. I'll be much prouder though if you continue to work towards concretely proving a medical basis for transsexuality, that is definitely a goal that would change the world and make many people much happier and safer.

Answer 2

YAY! I'd love it if you explained it more, sounds good. Will you explain it more, Ill hang around for your EDIT. Did you say that u found the CAUSE of why some people are born in a body with the opposite sex to their gender? Or did you find how you can CURE, as in, do a surgory who would fullly make the person into the opposite sex? (im dreaming rite?)


WOW! You are GOOD! I sort of understood ur first EDIT, but your second one tottaly confused me! But i guess i get the picture! I've never been good at science so its hard for me to understand those termonolgies, I just got a head spin reading the second edit, haha, but yeah I somehow get it, thanx for bothering to explain in further depth!
Your good! ;)

Answer 3

Sweetie, I have to confess I gave up on the explanation of what you did to make you so happy - but I am glad that it has made you happy.

Well, done!

I have no idea where you are, so I am eating your reward (three milk-chocolate Hob-nobs) for you.

A big whoo-hoo!!!
.

Answer 4

Wow dude!!! You rock.
I'm a bio major student and I would probably die in the process of doing all that research.

Hooray!

Answer 5

Wow- I would love to read your paper! Is there any way I can see a copy?

Answer 6

well i don't know you but i know the satisfaction of finishing a 10 page or more paper. so congrats. i hope you get great feedback

Answer 7

Great Job!

Answer 8

I'm proud of you, too!!!! That's going to make a difference in peoples' lives.

Answer 9

I am proud of you..even though you lost me at hello! Research papers are always difficult, but it sounds as though yours was particularly challenging.Congrats!

Answer 10

Intersexed people are awesome!