. Is it possible for a female to have hemophilia? a male?

Question

I know that hemophilia is a sex-linked disease caused by a recessive allele.

It's possible for both sexes to get it but way more likely for males right? IWhat genotypes of the parents that would be required for a female child or for a male child to have hemophilia.?

Answer 1

yes it is possible for females to get haemophilia though the incidence of its occuring is very less in them as they are generally carriers and require a pair of recessive alleles to express the condition which is possible only if the father was a haemophiliac, but earlier the haemophiliacs never lived long enough to father a child. however now there is an increasing population of both haemophiliac men and women as modern medicine has succeded in prolonging life even in these circumstances.
haemophilia A (factor VIII deficiency) with an incidence of between 1:5,000 and 1:10,000 males. Haemophilia B (factor IX deficiency) is less common, with an incidence of between 1:35,000 and 1:50,000 males. von Willebrands disease (von Willebrand factor deficiency) is a more common but generally milder bleeding disorder that affects at least 1 in a 1,000 people (both males and females).
in females however the incidence of haemophilia is 1000 times leeser as compared to males.

Answer 2

It is possible for both male and female to get haemophilia but more likely in male than female.

For a female to be haemophiliac her father has to be a haemophiliac and her mother a haemophiliac or a carrier.

The gene for haemophilia is carried on the non homologous portion of the X sex chromosome, so once a male gets the gene or rather the allele, he will have the disease as there is not a matching locus on the Y chromosome

Parental phenotype Carrier female Normal male
" genotype XHXh XHY

" gametes XH Xh XH Y

Offspring ggenotype XHXH XhXH XhY XHY

" Phenotype Normal F Carrier F H male N male

consider a carrier female mother and a haemophiliac father;

carrier F H - male

XHXh XhY

XH Xh Xh Y

XHXh XHY XhXh XhY

The above shows how it is possible that a female could be a haemophiliac; in this case there is 25 % probability.

Answer 3

Females cannot get hemophilia but they can be carriers. And sometimes the carriers also have the symptoms of hemophilia so also need treatment, but even when this happens they do not have hemophilia. They are considered carriers with symptoms. But females can get something called von Willebrand disease or vWD which is similar to hemophilia but can be found in both males and females. Hope this helps.

Answer 4

Yes, it is far more likely for a male to have hemophilia than a female. The hemophilia gene is rather uncommon in the population. A male child gets the allele from his mother on the X-chromosome. A female child has to get the recessive allele from both of her parents - on the X from her mom and on the X from her dad. So her parents must be XHXh and XhY where H is normal clotting and h is hemophilia.

I tell my students that it's like drawing marbles from a bowl. A boy only gets one draw. If he gets a marble that says he has hemophilia, he doesn't get another draw to override it. Girls get two draws. If they draw the marble that says hemophilia, they get another chance because they have two X-chromosomes.

Answer 5

Yes, both males and females can be haemophilic. The genes responsible for haemophilia is found on the 23rd X chromosome (sex chromosome). Females have 2 X chromosomes, one of which is inactivated (thus nothing is expressed from it). If the recessive gene is on that chromosome, the female will not have haemophilia. If it is on the active X chromosme, she will. Thus, if a female is heterozygous (one dominant, one recessive) she has a 50% chance of being haemophilic. Unfortunately, men only have one X, so if they have the recessive allele, they have a 100% chance of being haemophilic.

It used to be that any male who was haemophilic would be dead before he could have children. Thus, usually the males are dominant, and they'll only have one copy of the allele (as the Y chromosome doesn't have it). So, the mother would have to be heterozygous or homozygous recessive (two recessive copies). So, for males:
Father: Dominant
Mother: Heterozygous (or homozygous recessive)

For females:
Father: Recessive
Mother: Recessive (homozygous)

Answer 6

Yes it is way more likely for males to fet haemophilia than females. If the mother was a carrier and the father is a carrier than more than likely the male son will also have haemohilia. Males are more likely yo get the disease because it is found on the Y chromosome and since females have two X chromosomes they are at a lesser risk.

Answer 7

Females possess two X-chromosomes, whereas males have one X and one Y chromosome. Since the mutations causing the disease are recessive, a woman carrying the defect on one of her X-chromosomes may not be affected by it, as the equivalent allele on her other chromosome should express itself to produce the necessary clotting factors. However the Y-chromosome in men has no gene for factors VIII or IX. If the genes responsible for production of factor VIII or factor IX present on a male's X-chromosome is deficient there is no equivalent on the Y-chromosome, so the deficient gene is not masked by the dominant allele and he will develop the illness.

Since a male receives his single X-chromosome from his mother, the son of a healthy female silently carrying the deficient gene will have a 50% chance of inheriting that gene from her and with it the disease; and if his mother is affected with haemophilia, he will have a 100% chance of being a haemophiliac. In contrast, for a female to inherit the disease, she must receive two deficient X-chromosomes, one from her mother and the other from her father (who must therefore be a haemophiliac himself). Hence haemophilia is far more common among males than females. However it is possible for female carriers to become mild haemophiliacs due to lyonisation of the X chromosomes. Haemophiliac daughters are more common than they once were, as improved treatments for the disease have allowed more haemophiliac males to survive to adulthood and become parents. Adult females may experience menorrhagia (heavy periods) due to the bleeding tendency.The pattern of inheritance is criss-cross type.This type of pattern is also seen in colour blindness.

As with all genetic disorders, it is of course also possible for a human to acquire it spontaneously (de novo), rather than inheriting it, because of a new mutation in one of their parents' gametes. Spontaneous mutations account for about ⅓ of all haemophilia A and 1/5 of all haemophilia B cases. Genetic testing and genetic counseling is recommended for families with haemophilia. Prenatal testing, such as amniocentesis, is available to pregnant women who may be carriers of the condition.

If a female gives birth to a haemophiliac child, she is a carrier for the disease. Until modern direct DNA testing, however, it was impossible to determine if a female with only healthy children was a carrier or not. Generally, the more healthy sons she bore, the higher the probability that she was not a carrier. If the RH factor of the born male is different from the mother, the child will not be affected.

Answer 8

yes its possible
we know that men carry both x and y chromosomes
and women carry 2 x chromosome
defected=h not defected=H
so male with :XhY is affected
XHY not affected
female with: XhXh is affected
XHXH not affected
XHXh carrier
if the male have XhY to be punnet squared with a woman that have a genotype of XhXh then 100% of their child are affected.
but if the male is not affected- XHY crossed with a woman
carrier XHXh then their
children's genotypes (base on punnet square):
XHXH- one female is unaffected
XHXh- one female is a carrier
XHY- one male is unaffected
XhY- one male is affected

so we have 1 affected, 2 unaffected and 1 carrier
whew! thats all! My biology class really help me out! I hope this help u out, dont u know how to use punnet square?
im just a 2nd yr student, and i really love genetics.

Answer 9

females are usually known to be only the carriers of the so-called disease and show only symptoms such as excessive bleeding. males, however, are the ones who suffer the brunt of such disease causing almost if not endless bleeding. a known example of which is the romanov family. (check wikipedia to see the other symptoms)

Answer 10

it is possible to have a female with hemophilia, but both the father and the mother must have the gene for girls. In boys it's just father,i think