In 1826 What were the main highway from mason county va. to jackson Ms.?

Answer 1

You will probably have to go to a major university library that has a major map archive. UW-Milwaukee, where I happen to be right now, has the best map collection in the country.

The simple answer is there was very likely no one main highway, probably not even one main road. Most likely a series of smaller roads through a variety of larger crossroads such as Raleigh and Atlanta. But 1826 is fairly early in US history.

I found a site with maps of Alabama from the 1820s. That should give you some ideas about what roads were like during that time period:
http://alabamamaps.ua.edu/historicalmaps/alabama/1826-1840.html

The same site has maps of the US from 1820s:
http://alabamamaps.ua.edu/historicalmaps/unitedstates/1826-1850.html

and Individual states, including Virginia:
http://alabamamaps.ua.edu/historicalmaps/us_states/virginia/index.html

Answer 2

There was a highway from Mason Co. Va to Jackson Mississippi? I know about the National Road, the first major road in the U.S., but that connected Baltimore with the Ohio River Valley...