What are the factors involved in activating target cells by hormone-receptor interaction?

Question

I want to be throughal with my answer, so any info you can throw my way is greatly appreciated.

Answer 1

A. Steroid Hormones and Gene Expression. These hormones pass through the target cell and into the nucleus where they bind to a receptor protein. Here they activate certain genes.

B. Peptide Hormones and Second Messengers. They are unable to pass through the plasma membrane and have different methods of action. They attach to their receptors in the target cell surface and influence activity within the cell through cytoplasmic intermediates called second messengers.

The two most important messengers are cAMP and inositol triphosphate.

Cyclic AMP: ATP is converted into cAMP after a series of reactions on the plasma membrane following the attachment of the hormone to the membrane. cAMP relays the signal from the membrane to the metabolic machinery of the cytoplasm.
Inositol Triphosphate: Involves the use of Ca+2 that regulates cellular protein activity.

Answer 2

this could be a annoying one !! there are a number of factors that are in touch...you will possibly be able to might desire to slender your concentration.. Ligand-gated channels, G proteins and cAMP are all in touch which change on or inactivate the ok-Na pump which impacts a good purchase of issues. then you certainly've the excellent agonist/antagonist area. All i will say is that "receptor-mediated responses to drugs and hormonal agonists regularly desensitize with time". Katzung pg. 23