Sickle cell is caused by a point mutation in the gene for hemoglobin that changes a single amino acid in the sequence of the protein. The mutation causes hemoglobin's structure to change when oxygen is not bound to it. This conformational change in the shape of hemoglobin alters the shape of the red blood cell so that instead of being a biconcave disc, it is flat with sharp edges or "sickled." Sickle cells do not fit through capillaries very well and are prone to breaking or lysis. When the cells lyse, they are no longer able to carry oxygen in the blood. This results in anemia.
Sickle cell disease is a condition where both alleles from a person's parents carry the mutation. Sickle cell trait is when a person has one allele with the sickle cell mutation and one allele with the normal hemoglobin gene. Sickle cell trait is less severe and can be controlled quite well under normal circumstances.
2007-03-24 08:04:44
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answer #1
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answered by Erik S 2
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I think you mean sickle cell.
Sickle cell anemia is a condition in which your normally round red blood cells build up protein and become shaped like Cs, or sickles. This shape is harmful because it can cause cells to get stuck or block capillaries. Also, the cells cannot transport Oxygen from the lungs to the organs anymore.
Sickle cell is a recessive trait, meaning you must have two copies of the gene to get sickle cell anemia. But, sickle cell is also a special case, where if you have one copy of the gene, some of your cells will sickle under special conditions (such as high altitude).
One of those conditions is if you are infected with Malaria. When the virus enters your blood cell, the cell is triggered to sickle. The virus cannot function under the sickle conditions and is thus stopped. So people with one copy of the sickle cell trait are immune to Malaria. But people with two copies of the trait will have anemia and become very sick.
2007-03-24 07:57:16
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answer #2
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answered by retzy 4
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Sickle Cell Anemia is a disease more common to the black population where there is basically a defect in the hemoglobin and that makes the red blood cell be shaped in a crescent moon shape (or sickle) rather than its normal round form.
This is kind of difficult to explain to a non medical person. To have sickle cell anemia, you need to have two of the genes of sickle cell (SS). If a person only has one gene, then they have Sickle Cell trait. The people with the trait can pass it along, and they get a mild form of anemia as opposed with people with Sickle cell anemia who get a severe form of anemia.
If you have sickle cell trait you may live a normal life.
2007-03-24 08:02:15
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answer #3
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answered by Dr. H 2
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Sickle cell trait means you are a carrier for sickle cell anemia. It takes two Sikcle cell genes to have the disease but only one to have the trait. As a carrier you can pass this trait or disease to future generations therefore conselling might be appropriate before starting a family. You are unlikely to be bothered by the trait as only a small amount of your blood will have the abnormal hemoglobin and it typically isn't enough to effect quality of life.
2007-03-24 08:24:51
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answer #4
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answered by atrxnasd 1
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sickle cell is a hereditary (passed down from one family member to another thru the blood) condition that occurs when a person inherits from only one parent the abnormal hemoglobin gene characteristic of sickle cell anemia. the red blood cells "sickle" or are misshappen in such a way that oxygen is not delivered as well to each cell. there is no cure.
If you have sickle cell trait and your partner does not, your children each have a 50% chance of having the sickle cell trait, and a 50% chance of having normal hemoglobin. If you have sickle cell trait it is extremely important that your partner is tested. If you and your partner both have sickle cell trait there is a 25% chance of the child having normal hemoglobin, a 50% chance of the child having the sickle cell trait, and a 25% of having sickle cell disease.
2007-03-24 08:03:27
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answer #5
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answered by Kensey C 1
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VERY good question it makes sense know to me!!
red blood cells shaped in C is there a cure ?
2007-03-24 08:00:21
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answer #6
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answered by jose b 1
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i think you may be talking of 'sickle cell' anaemia?
2007-03-24 07:56:36
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answer #7
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answered by rara avis 4
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